Possibilities of non-invasive post-genomics technologies in the prediction and early diagnosis of preeclampsia


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. To search and analyze the literature devoted to the study of possible markers and predictors of preeclampsia (PE), with the use of post-genomics technologies in particular. Material and methods. Articles were searched in the database Pubmed. The review includes the data of foreign and Russian articles published in the past 15 years. Results. The markers identified so far are shown to relate to early PE. The paper presents the results of postgenomics studies based on omics technologies. It shows the possibility of using the urine congophilia phenomenon as a new screening method. Conclusion. It is necessary to conduct further investigations to develop a panel of non-invasive markers for PE in biological fluids, by using a proteomic and further urinary peptidome analysis as an example, which, reflecting the multifactorial pattern of PE, can simultaneously serve as both a predictor and a tool for monitoring the course of the disease, being a key component of personalized medicine.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Kamilla Muminova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kamika9i@mail.ru
junior researcher, ist obstetrical department of pathology of pregnancy

Әдебиет тізімі

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