The fallopian tubes in genital pathology and intratubal therapy for female infertility

Objective. To conduct a retrospective, comparative study of the morphological state of the fallopian tubes. Subjects and methods. Histological, immunohistochemical and morphometric examinations were used to examine the histological specimens of the fallopian tubes in 714 reproductive-aged women. Among them, there were 127 women diagnosed with nonspecific cervical inflammatory processes, 122 with uterine fibroids, 177 with genital endometriosis and uterine adenomyosis, and 223 women with benign ovarian cysts. The fallopian tube specimens from 65 women without genital pathology served as a control. Results. The findings were analyzed taking into account the assessment of structural elements in different parts of the fallopian tube, the thickness of its wall layers, the characteristics of arterial and venous blood supply and microarchitecture of the fallopian tube wall in different phases of the ovarian and menstrual cycle in concomitant extratubal pathology of the genital tract. The findings were compared with the histological and morphometric data of the control group, without indicating concomitant genital pathology in the clinical protocol. Conclusion. The finding may lead to the conclusion that the observed changes in the fallopian tube wall in various types of genital tract pathology play an important role as a morphological substrate for the clinical data related to the low efficiency of assisted reproductive technologies. This study makes it possible to clarify a diagnostic algorithm and to introduce a novel method for the treatment of patients in a female infertility clinic.

macromicroscopic changes in the wall of the fallopian tube, nonspecific inflammatory processes of the cervix uteri, uterine myoma, endometriosis, adenomyosis, benign ovarian cysts, infertility