Bone metabolism in periand postmenopausal women with type 1 diabetes mellitus

Aim. To estimate the effect of type 1 diabetes mellitus on bone mineral density and bone metabolism parameters in women; determ ine the direction of changes in serum bone remodeling markers and BMD in the peri- and post-menopausal women with this disease. Material and methods. The study comprised 57peri- and post-menopausal women with type 1diabetes (study group) and 43 women in the control group. Diagnostic evaluation included analysis of BMD using DXA and expressed as T-score, and serum bone remodeling markers (ALP, P1NP and b-CTx). Results. The findings showed the inconsistency of changes in bone remodeling in patients with type 1 diabetes mellitus (35.5% and 16.6%, p <0.001) with a predominant change in bone formation. The duration of diabetes had a positive correlation with serum b-CTXconcentration (r = 0.349, p = 0.008). A negative correlation was found between the change in T-score at the lumbar spine and the duration of diabetes (r = -0.239, p = 0.03). There was a statistically signif icant correlation between T-score at the lumbar spine and serum b-CTX level (r = -0.452, p = 0.002). Conclusion. The findings of this study suggest that changes in bone metabolism in the majority of patients are associated with bone formation inhibition and, to a much lesser extent, bone resorption accelerating during the late perimenopause, continuing at similar rates in the early years of postmenopause, and decreasing bone loss later.

type 1 diabetes mellitus, postmenopause, osteoporosis, bone mineral density