Bone metabolism in periand postmenopausal women with type 1 diabetes mellitus
- Autores: Safarova S.S.1
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Afiliações:
- Azerbaijan Medical University
- Edição: Nº 9 (2018)
- Páginas: 80-84
- Seção: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248324
- DOI: https://doi.org/10.18565/aig.2018.9.80-84
- ID: 248324
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Resumo
Aim. To estimate the effect of type 1 diabetes mellitus on bone mineral density and bone metabolism parameters in women; determ ine the direction of changes in serum bone remodeling markers and BMD in the peri- and post-menopausal women with this disease. Material and methods. The study comprised 57peri- and post-menopausal women with type 1diabetes (study group) and 43 women in the control group. Diagnostic evaluation included analysis of BMD using DXA and expressed as T-score, and serum bone remodeling markers (ALP, P1NP and b-CTx). Results. The findings showed the inconsistency of changes in bone remodeling in patients with type 1 diabetes mellitus (35.5% and 16.6%, p <0.001) with a predominant change in bone formation. The duration of diabetes had a positive correlation with serum b-CTXconcentration (r = 0.349, p = 0.008). A negative correlation was found between the change in T-score at the lumbar spine and the duration of diabetes (r = -0.239, p = 0.03). There was a statistically signif icant correlation between T-score at the lumbar spine and serum b-CTX level (r = -0.452, p = 0.002). Conclusion. The findings of this study suggest that changes in bone metabolism in the majority of patients are associated with bone formation inhibition and, to a much lesser extent, bone resorption accelerating during the late perimenopause, continuing at similar rates in the early years of postmenopause, and decreasing bone loss later.
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Sobre autores
Sain Safarova
Azerbaijan Medical University
Email: sainsafarova@gmail.com
MD, associate professor of the Department of Internal Diseases III, medical-prophylactic faculty II
Bibliografia
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Arquivos suplementares
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