New opportunities of clomiphene citrate treatment for functional hypothalamic amenorrhea
- Авторлар: Chernukha G.E.1, Gusev D.V.1, Tabeeva G.I.1, Marchenko L.A.1
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Мекемелер:
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
- Шығарылым: № 3 (2019)
- Беттер: 84-90
- Бөлім: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248442
- DOI: https://doi.org/10.18565/aig.2019.3.84-90
- ID: 248442
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Objective. To evaluate the efficiency of clomiphene citrate (CC) therapy for functional hypothalamic amenorrhea (FHA). Subjects and methods. A total of 84 patients with FHA underwent clinical and laboratory examinations. The patients received down-step therapy with CC, by reducing its cycle dose and use duration. The response to CC was rated as complete, partial, or absent in terms of the presence of menses and their preservation after therapy discontinuation. Results. Menses were observed to appear in 76.2% of the patients during the therapy; these preserved in 23.8% after its discontinuation. The predictors of response to therapy as recovery of the intrinsic rhythm of menstruation included LH levels > 2.71 IU/l, estradiol > 106.5 nmol/l, LH/FSH > 0.88, and BMI > 20.6 kg/m2. Conclusion. Down-step CС therapy may contribute to sensitization of the hypothalamic-pituitary-ovarian axis, to the appearance of menstruations in 76.2% of the patients, and to their subsequent preservation in every three of them.
Негізгі сөздер
Толық мәтін
Авторлар туралы
Galina Chernukha
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: c-galina1@yandex.ru
MD, professor
Dmitry Gusev
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: doctor.dgusev@gmail.com
postgraduate student
Guzyal Tabeeva
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: doctor.gtab@gmail.com
PhD, senior researcher
Larisa Marchenko
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: l_marchenko@yandex.ru
MD, professor
Әдебиет тізімі
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