Menopause, obesity, and comorbidity: possibilities of menopausal hormone therapy


Дәйексөз келтіру

Толық мәтін

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Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The steady increase in cancer incidence rates necessitates studies of global risk factors for cancer and a search for novel methods of effective primary prevention. According to the International Cancer Research Agency (IARC, 2017), obesity also increases the risk for development of 13 most common malignant neoplasms (MNs), including breast, colon, pancreas, bladder, and endometrial cancers; the incidence of MNs caused by overweight and obesity among women is 5.4%. Menopausal metabolic syndrome (metabolic syndrome associated with the development of hypogonadism) occurs in 40% of postmenopausal women. Menopausal hormone therapy (MHT) for women in the early postmenopause and/or those who are younger than 60 years, and overweight control reduces overall mortality from 30 to 52% and contributes to the primary prevention of a number of MNs, including breast cancer, type 2 diabetes mellitus, and cardiovascular disease. In addition to MHT, lifestyle modification should be recommended to control body weight and to increase physical activity.

Толық мәтін

Рұқсат жабық

Авторлар туралы

A. Protasova

Saint Petersburg State University; V.A. Almazov National Medical Research Center, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University; OOO «AVA-PETER»

Email: protasova1966@yandex.ru

S. Yureneva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: syureneva@gmail.com

N. Bairamova

Saint Petersburg State University; OOO «AVA-PETER»

Email: nurana.bayramova@yandex.ru

V. Komedina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: komedina.veronika@gmail.com

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