GENETIC AND EPIGENETIC MECHANISMS OF GENITAL ENDOMETRIOSIS-ASSOCIATED INFERTILITY


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Abstract

This review analyzes a literature database including systematic reviews and randomized clinical trials devoted to current ideas on the pathogenesis of genital endometriosis-associated infertility. The 2012-2019publications available in the databases PubMed, MedLine, and Crossref underwent analysis. Endometriosis is considered as a multifactorial disease, the pathogenesis of which involves both genetic and environmental factors. This review demonstrates the role of genetic and epigenetic influences in the development of endometriosis and its associated infertility. It presents recent studies of the impact of oxidative stress accompanying endometriosis on fertility.

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About the authors

Oxana A. Melkozerova

Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation

Email: abolmedl@mail.ru
МD, Deputy of Director for Science, Head of department reproductive functions preservation Yekaterinburg, Russia

Nadezda V. Bashmakova

Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation

Email: bashmakovanv@niiomm.ru
MD, Prof., Honored Doctor of the Russian Federation, Head of department of ART, Chief obstetrician-gynecologist of the Ural Federal District, Chief Researcher Yekaterinburg, Russia

Ekaterina O. Okulova

Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation

Email: cat93_07@mail.ru
obstetrician-gynecologist, department of department reproductive functions preservation Yekaterinburg, Russia

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