The development of atypical hemolytic uremic syndrome in the presence of HELLP syndrome

Background. Obstetric thrombotic microangiopathies (TMA) in pregnancy develop in 8-18% of all TMA cases and are one of the causes of maternal and perinatal deaths. The diagnosis in the shortest possible time and the speed of pathogenetic therapy initiation are the basic factors that influence disease outcomes and further prognosis in a woman. Description. The paper presents a rare clinical case of a 33-year-old female patient with the malignant course of atypical hemolytic uremic syndrome (aHUS) in the presence of HELLP syndrome. It describes the clinical, anamnestic, laboratory, and instrumental data of the patient, and the features of her management and treatment. Conclusion. Early diagnosis, timely initiation of plasmotherapy, pathogenetic treatment on 4 days after the onset of aHUS in the malignant course of aHUS with severe multiple organ dysfunction could quickly achieve not only a hematologic response, but also completely restore the function of the kidneys and other affected organs.

obstetric thrombotic microangiopathy, HELLP syndrome, atypical hemolytic uremic syndrome, microangiopathic hemolytic anemia, thrombocytopenia, plasma exchange