Treatment for vaginitis in pregnancy


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Аннотация

Objective. To comparatively evaluate the clinical and laboratory effectiveness of different treatment regimens for vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV) in pregnant women in the second and third trimesters. Subjects and methods. Sixty-five patients with VVC and BV were examined and treated in the second and third trimesters of pregnancy. Group 1 consisted of 35pregnant women with first diagnosed disease; Group 2 included 30patients with recurrent disease. A short 3-day Gynomax treatment regimen or a long 7-day Gynomax one was used. Results. Before treatment, there were increases in bacterial mass (11.2±1.7Log) and in the number of aerobic and anaerobic microorganisms (6.2 (1.4) Log); as well as obvious Lactobacillus deficiency (3.1 (1.1) Log). Vaginal pH was more than 5.2 in 35/65 (53.8%) women. After applying the seven-day Gainomax treatment regiment, complaints of vaginal discharge and itching persisted in 1/15 (6.6%) women; there were decreases in the total bacterial mass to 7.4 (1.2) Log and in aerobic and anaerobic flora to 2.4 (0.6) Log. Following the three-day use of the drug, pathological discharge and vulvar pruritus persisted in 2/15 (13.3%) of the pregnant women; the bacterial mass was much as 8.2 (1.7) Log; the concentration of aerobic and anaerobic flora was 3.9 (1.5) Log. Conclusion. Both short- and long-course treatment regimens are equally effective during new-onset dysbiosis and VVC in pregnant women in the second and third trimesters. The seven-day regimen has an advantage in recurrent disease.

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Авторлар туралы

N. Katkova

Volga Research Medical University, Ministry of Health of Russia

Email: katkovanu@inbox.ru
MD; Head, Department of Obstetrics and Gynecology 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia

O. Guseva

Volga Research Medical University, Ministry of Health of Russia

Email: alise52@yandex.ru
MD, Professor, Department of Obstetrics and Gynecology 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia

O. Kachalina

Volga Research Medical University, Ministry of Health of Russia

Email: yander24@bk.ru
MD; Professor, Department of Obstetrics and Gynecology 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia

A. Soshnikov

Volga Research Medical University, Ministry of Health of Russia

Email: artvals@mail.ru
Cand. Med. Sci.; Associate Professor, Department of Obstetrics and Gynecology 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia

V. Malyshev

Volga Research Medical University, Ministry of Health of Russia

Email: slavnyidoc@mail.ru
Cand. Med. Sci.; Associate Professor, Department of Obstetrics and Gynecology 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia

M. Zaslavskaya

Volga Research Medical University, Ministry of Health of Russia

Email: maya_zaslav@rambler.ru
BD, Professor, Department of Epidemiology, Microbiology, and Evidence-Based Medicine 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia

A. Sergeeva

Volga Research Medical University, Ministry of Health of Russia

Email: sergeeva-av2013@yandex.ru
Cand. Med. Sci.; Associate Professor, Professor, Department of Epidemiology, Microbiology, and Evidence-Based Medicine 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia

Әдебиет тізімі

  1. Ходжаева З.С., Припутневич Т.В., Муравьева В.В., Гусейнова Г.Э., Горина К.А. Оценка состава и стабильности микробиоты влагалища у беременных в процессе динамического наблюдения. Акушерство и гинекология. 2019;7:30-38
  2. Кузьмин В.Н. Практические аспекты лечения неспецифических и кандидозных вульвовагинитов у женщин во время беременности. Гинекология. 2009; 11(2): 12-5
  3. Карапетян Т.Э., Арзуманян В.Г., Тютюнник В.Л., Кан Н.Е., Ломова Н.А., Канюкина А.А. Бактериальный вагиноз и антимикробная активность во время беременности. Акушерство и гинекология. 2018;8:85-90
  4. Кедрова А.Г., Леваков С.А., Красильников С.Э., Ванке Н.С., Габитова Н.А. Стратегия диагностикии лечения вульвовагинальных болезней. М.: НП Русмедикал групп; 2015. 56 с
  5. Тихомиров А.Л. Эффективная локальная терапия вагинальных белей. Гинекология. 2015; 17(4): 54-5
  6. Григорян О.Р., Андреева Е.Н. Ожирение и репродуктивная функция. Акушерство и гинекология. 2015; 9: 14-9

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