The efficiency of using menotropins in the general patient population in the ivf protocols in the Northwestern Region of Russia

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective: To evaluate the clinical efficiency and safety of using highly purified human menopausal gonadotropins (HP hMG) in the IVF protocols in existing clinical practice in the protocols with GnRH agonists and antagonists in the Northwestern Region of Russia.

Materials and methods: A multicenter open-label observational study was conducted in 13 centers in the Northwestern Region of Russia. During 3 years from 2017 to 2020, the study enrolled 1504 patients aged 20 to 43 years who were treated for infertility by assisted reproductive technologies (IVF).

Results: There were high clinical pregnancy rates per started cycle (50.0%), high live birth rate per embryo transfer (43.1%), with a low transfer cancellation rate (5.4%), including an extremely low risk for ovarian hyperstimulation syndrome (1.4%).

Conclusion: Taking into account the high efficacy and safety, the authors can recommend the use of HP hMG as first-line drugs of choice in the general population when stimulating superovulation in the IVF protocols.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Dmitry Gerkulov

Skyfert Clinic of Reproduction

Хат алмасуға жауапты Автор.
Email: gerkulov@gmail.com

PhD

Ресей, Saint Petersburg

Alla Kalugina

I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia; Skyfert Clinic of Reproduction

Email: gerkulov@gmail.com

Dr. Med. Sci., Professor, Department of Obstetrics, Gynecology and Neonatology; obstetrician-gynecologist, reproductologist, General Director

Ресей, Saint Petersburg; Saint Petersburg

Әдебиет тізімі

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2. Figure. Outcomes of IVF protocols

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