New approaches to studying the regulation of preimplantation embryonic development

Мұқаба

Дәйексөз келтіру

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Аннотация

Only 40% of embryos obtained in ART programs are known to develop to the blastocyst stage; the remaining embryos stop developing at different division stages. The genetic and epigenetic factors of both the very embryo itself and the oocyte, which play a key role in the early preimplantation embryonic development, are of great importance in the genesis of infertility.

This review discusses new approaches to studying the regulation of preimplantation embryo development, analyzes the impact of the genetic and epigenetic status of oocytes on the quality of obtained embryos and the rate of pregnancy. It gives the data of investigations in this area and promises of their use in clinical practice. On the strength of thee available data, the authors consider the possibility of overcoming severe infertility forms associated with a small number of obtained embryos and their poor quality; that of overcoming a condition, such as infertility of unclear genesis; they also discuss the possibility of searching for new methods for assessing the quality of oocytes and embryos to improve IVF programs. The review underlines the need for expanding and intensifying the investigations determining the epigenetic status of an embryo and the corresponding oocyte, those studying the processes of epigenetic regulation in the early embryo development.

The paper analyzes the data of researches in the epigenetic regulation of preimplantation embryonic development, characterizes the main epigenetic modifications affecting the quality of obtained oocytes and embryos, and identifies the possibility of clinical application of the available data.

Conclusion: At the present stage, the methods for assessing the quality of obtained embryos are based on morphological criteria. However, the morphological assessment grounded mainly on the visual determination of the degree of their competence does not correlate with the capability of embryos for implantation and development of high-quality pregnancy to a sufficient extent. In this connection, it is expedient to study the molecular genetic characteristics of embryos during the period of early embryonic development to devise clinical and pathogenetic methods to enhance the efficiency of infertility treatment in the IVF programs.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Yana Martirosyan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Хат алмасуға жауапты Автор.
Email: marti-yana@yandex.ru

PhD, gynecologist at F. Paulsen Scientific and Clinical Department

Ресей, Moscow

Tatiana Nazarenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: t_nazarenko@oparina4.ru

Professor, Dr. Med. Sci., Director of the Institute of Reproductive Medicine

Ресей, Moscow

Albina Kadaeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: albina.karimovai@mail.ru

clinical resident specializing in obstetrics and gynecology

Ресей, Moscow

Valeria Krasnova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: lkrasnova27@mail.com

clinical resident at F. Paulsen Scientific and Clinical Department

Ресей, Moscow

Almina Biryukova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: a_birukova@oparina4.ru

gynecologist at F. Paulsen Scientific and Clinical Department

Ресей, Moscow

Mariam Pogosyan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: Mariam-pogosyan@yandex.ru

Ph.D. student, F. Paulsen Scientific and Clinical Department

Ресей, Moscow

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