Clinical and anamnestic features of diseases of the cervix

Мұқаба

Дәйексөз келтіру

Толық мәтін

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Аннотация

Objective: Investigation of risk factors for tumor transformation based on the study of clinical and anamnestic features of the course of various pathological processes in the cervix.

Materials and methods: The study included 210 female patients of reproductive age, who were divided into 5 groups: group 1 consisted of 37 women with cytological findings "NILM"+high carcinogenic risk of human papillomavirus (HR HPV); group 2 consisted of 43 women with cytological findings "LSIL"+HR HPV; group 3 consisted of 46 patients with cytological findings "HSIL"+HR HPV; group 4 comprised 39 patients with cytological findings "NILM", hyperkeratosis of squamous epithelium an absence of HPV; group 5 (the comparison group) comprised 45 women with cytological findings "NILM" and the absence of HPV.

Results: The severity of cervical intraepithelial lesions was not associated with the age of patients and the intake of oral contraceptives. The patients with LSIL+HR HPV and HSIL+HR HPV had early sexual debut (the average age of 17 years), (p<0,001). It was found that the severity of intraepithelial lesions and duration of HPV persistence depended on the number of sexual partners (p<0,001). The largest number of smoking patients (51.2% and 41,3%) and women with early sexual debut were in the groups with mild and severe cervical intraepitheliasl lesions in combination with HR HPV (p<0.001). Sexually transmitted infections were significantly more common in women infected with HR HPV. A combination of endometriosis, uterine fibroids, endometrial hyperplasia and benign mammary dysplasia was found in patients with HPV and squamous intraepithelial lesions of the cervix (p<0.001).

Conclusion: Analysis of the anamnestic data and specific features of the clinical cause of pathological processes in the cervix confirmed again the significance of the importance of certain factors in tumor formation and transformation of cervical epithelial cells.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Sergey Levakov

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Хат алмасуға жауапты Автор.
Email: levakoff@yandex.ru

Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM

Ресей, Moscow

Natalia Sheshukova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: dr.sheshukova@mail.ru

Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM

Ресей, Moscow

Elizaveta Obukhova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: liza_obukhova@mail.ru

Teaching Assistant at the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM

Ресей, Moscow

Makhluga Dzhafarova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: goglu55@mail.ru

graduate student at the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM

Ресей, Moscow

Mariam Kaviladze

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: mariam-kaviladze@mail.ru

Teaching Assistant and graduate student at the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM

Ресей, Moscow

Әдебиет тізімі

  1. Морхов К.Ю., Нечушкина В.М., Кузнецов В.В. Индукционная химиотерапия местнораспространенного рака шейки матки. Вопросы онкологии. 2015; 61(2): 208-13. [Morkhov K.Y., Nechushkina V.M., Kuznetsov V.V. Induction chemotherapy for locally advanced cervical cancer. Problems in Oncology. 2015; 61(2): 208-13. (in Russian)].
  2. Lagunas-Martínez A., Madrid-Marina V., Gariglio P. Modulation of apoptosis by early human papillomavirus proteins in cervical cancer. Biochim. Biophys. Acta. 2010; 1805(1): 6-16. https://dx.doi.org/10.1016/j.bbcan.2009.03.005.
  3. Леваков С.А., Шешукова Н.А., Пауков С.В., Обухова Е.А. Доброкачественные и преинвазивные состояния шейки матки. Учебно-методическое пособие. Практическая медицина; 2022. 63с. [Levakov S.A., Sheshukova N.A., Paukov S.V., Obukhova E.A. Benign and preinvasive conditions of the cervix. Educational and methodological manual. Practical medicine; 2022. 63p. (in Russian)].
  4. Teixeira N.C.P., Araújo A.C.L., Correa C.M., da Costa Lodi C.T., Lima M.I.M., de Oliveira Carvalho N. et al. Prevalence and risk factors for cervical intraepithelial neoplasia among HIV-infected women. Braz. J. Infec.t Dis. 2012; 16(2): 164-9. https://dx.doi.org/10.1016/s1413-8670(12)70299-4.
  5. Thorsteinsson K., Ladelund S., Jensen-Fangel S., Katzenstein T.L., Somuncu Johansen I., Pedersen G. et al. Incidence of cervical dysplasia and cervical cancer in women living with HIV in Denmark: Comparison with the general population. HIV Med. 2016; 17(1): 7-17. https://dx.doi.org/10.1111/hiv.12271.
  6. Fonseca-Moutinho J.A. Smoking and cervical cancer. ISRN Obstet. Gynecol. 2011; 2011: 847684. https://dx.doi.org/10.5402/2011/847684.
  7. Su B., Qin W., Xue F., Wei X., Guan Q., Jiang W. et al. The relation of passive smoking with cervical cancer: a systematic review and meta-analysis. Medicine (Baltimore). 2018; 97(46): e13061. https://dx.doi.org/10.1097/MD.0000000000013061.
  8. Sugawara Y., Tsuji I., Mizoue T., Inoue M., Sawada N., Matsuo K. et al.; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Cigarette smoking and cervical cancer risk: An evaluation based on a systematic review and meta-analysis among Japanese women. Jpn. J. Clin. Oncol. 2019; 49(1): 77-86. https://dx.doi.org/10.1093/jjco/hyy158.
  9. Dutta T., Haderxhanaj L., Agley J., Jayawardene W., Meyerson B. Association between individual and intimate partner factors and cervical cancer screening in Kenya. Prev. Chronic Dis. 2018; 15: E157. https://dx.doi.org/10.5888/pcd15.180182.
  10. Endalew D.A., Moti D., Mohammed N., Redi S., Alemu B.W. Knowledge and practice of cervical cancer screening and associated factors among reproductive age group women in districts of Gurage zone, Southern Ethiopia. A cross-sectional study. PLoS One. 2020; 15(9): e0238869. https://dx.doi.org/10.1371/journal.pone.0238869.
  11. Kaneko N. Factors associated with cervical cancer screening among young unmarried Japanese women: Results from an internet-based survey. BMC Womens Health. 2018; 18(1): 132. https://dx.doi.org/10.1186/ s12905-018-0623-z.
  12. Vanakankovit N., Taneepanichskul S. Effect of oral contraceptives on risk of cervical cancer. J. Med. Assoc. Thai. 2008; 91(1): 7-12.
  13. La Vecchia C., Boccia S. Oral contraceptives, human papillomavirus and cervical cancer. Eur. J. Cancer Prev. 2014; 23(2): 110-2. https://dx.doi.org/10.1097/CEJ.0000000000000000.
  14. Bedoya A.M., Tate D.J., Baena A., Córdoba C.M., Borrero Mauricio, Pareja R. et al. Immunosuppression in cervical cancer with special reference to arginase activity. Gynecol. Oncol. 2014; 135(1): 74-80. https://dx.doi.org/10.1016/ j.ygyno.2014.07.096.
  15. Dugué P.-A., Rebolj M., Garred P., Lynge E. Immunosuppression and risk of cervical cancer. Expert Rev. Anticancer Ther. 2013; 13(1): 29-42. https://dx.doi.org/10.1586/era.12.159.
  16. Clure C., Rivard C. Primary herpes simplex virus infection mimicking a cervical malignancy in an immunocompetent individual. Cureus. 2018; 10(6): e2753. https://dx.doi.org/10.7759/cureus.2753.
  17. Kenarkoohi A., Bamdad T., Soleimani M., Soleimanjahi H., Fallah A., Falahi S. HSV-TK expressing mesenchymal stem cells exert inhibitory effect on cervical cancer model. Int. J. Mol. Cell. Med. 2020; 9(2): 146-54. https://dx.doi.org/10.22088/IJMCM.BUMS.9.2.146.
  18. Gadducci A., Barsotti C., Cosio S., Domenici L., Genazzani A.R. Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature. Gynecol. Endocrinol. 2011; 27(8): 597-604. https://dx.doi.org/10.3109/ 09513590.2011.558953.
  19. Maseko F.C., Chirwa M.L., Muula A.S. Health systems challenges in cervical cancer prevention program in Malawi. Glob. Health Action. 2015; 8: 26282. https://dx.doi.org/10.3402/gha.v8.26282.
  20. Murfin J., Irvine F., Meechan-Rogers R., Swift A. Education, income and occupation and their influence on the uptake of cervical cancer prevention strategies: a systematic review. J. Clin. Nurs. 2020; 29(3-4): 393-415. https://dx.doi.org/10.1111/jocn.15094.
  21. Sundström K., Miriam Elfström K. Advances in cervical cancer prevention: efficacy, effectiveness, elimination? PLoS Med. 2020; 17(1): e1003035. https://dx.doi.org/10.1371/journal.pmed.1003035.

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2. Fig. 1. Analysis of the age of the patients in the studied groups

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3. Fig. 2. Analysis of the age of sexual debut in the studied groups

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4. Fig. 3. Analysis of the peculiarities of sexual life in the studied groups

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5. Fig. 4. Dependence of HPV persistence on the number of sexual partners

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6. Fig. 5. Analysis of the number of pregnancies in the studied groups

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7. Fig. 6. Average number of births in the study groups

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8. Fig. 7. Average number of abortions in the studied groups

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9. Fig. 8. Duration of the presence of cervical ectopia in the studied groups

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10. Fig. 9. Duration of HPV-HCR persistence in the studied groups

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11. Fig. 10. Number of smoking patients in the studied groups

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12. Fig. 11. Analysis of the correlation between the presence of urogenital infection and HPV-HCV infection

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