Clinical and anamnestic features of diseases of the cervix
- Authors: Levakov S.A.1, Sheshukova N.A.1, Obukhova E.A.1, Dzhafarova M.M.1, Kaviladze M.G.1
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Affiliations:
- I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
- Issue: No 9 (2023)
- Pages: 122-128
- Section: Original Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/622970
- DOI: https://doi.org/10.18565/aig.2023.90
- ID: 622970
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Abstract
Objective: Investigation of risk factors for tumor transformation based on the study of clinical and anamnestic features of the course of various pathological processes in the cervix.
Materials and methods: The study included 210 female patients of reproductive age, who were divided into 5 groups: group 1 consisted of 37 women with cytological findings "NILM"+high carcinogenic risk of human papillomavirus (HR HPV); group 2 consisted of 43 women with cytological findings "LSIL"+HR HPV; group 3 consisted of 46 patients with cytological findings "HSIL"+HR HPV; group 4 comprised 39 patients with cytological findings "NILM", hyperkeratosis of squamous epithelium an absence of HPV; group 5 (the comparison group) comprised 45 women with cytological findings "NILM" and the absence of HPV.
Results: The severity of cervical intraepithelial lesions was not associated with the age of patients and the intake of oral contraceptives. The patients with LSIL+HR HPV and HSIL+HR HPV had early sexual debut (the average age of 17 years), (p<0,001). It was found that the severity of intraepithelial lesions and duration of HPV persistence depended on the number of sexual partners (p<0,001). The largest number of smoking patients (51.2% and 41,3%) and women with early sexual debut were in the groups with mild and severe cervical intraepitheliasl lesions in combination with HR HPV (p<0.001). Sexually transmitted infections were significantly more common in women infected with HR HPV. A combination of endometriosis, uterine fibroids, endometrial hyperplasia and benign mammary dysplasia was found in patients with HPV and squamous intraepithelial lesions of the cervix (p<0.001).
Conclusion: Analysis of the anamnestic data and specific features of the clinical cause of pathological processes in the cervix confirmed again the significance of the importance of certain factors in tumor formation and transformation of cervical epithelial cells.
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About the authors
Sergey A. Levakov
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Author for correspondence.
Email: levakoff@yandex.ru
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM
Russian Federation, MoscowNatalia A. Sheshukova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: dr.sheshukova@mail.ru
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM
Russian Federation, MoscowElizaveta A. Obukhova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: liza_obukhova@mail.ru
Teaching Assistant at the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM
Russian Federation, MoscowMakhluga M. Dzhafarova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: goglu55@mail.ru
graduate student at the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM
Russian Federation, MoscowMariam G. Kaviladze
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: mariam-kaviladze@mail.ru
Teaching Assistant and graduate student at the Department of Obstetrics and Gynecology of N.V. Sklifosovsky ICM
Russian Federation, MoscowReferences
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