Perinatal outcomes and characteristics of placental disorders in term pregnancies among convalescents after novel coronavirus infection (COVID-19) experienced at different gestational ages

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Дәйексөз келтіру

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Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective: To evaluate perinatal outcomes and the characteristics of placental disorders in term pregnancies among convalescents after COVID-19, experienced at different gestational ages.

Materials and methods: This study included 120 patients. The main group consisted of 80 women who gave birth at a gestational age of 370–416 weeks during the recovery period after COVID-19 and experienced various trimesters of pregnancy. The control group included 30 women without COVID-19 during their current pregnancy, who also gave birth at term. A retrospective analysis was conducted to assess obstetric and gynecological history, somatic pathology, course of pregnancy and childbirth, perinatal outcomes, and placental disorders.

Results: Convalescents after COVID-19, regardless of gestational age, who received low molecular weight heparin in prophylactic doses and vitamins C, E, and D in an extended regimen, exhibited favorable perinatal outcomes in term pregnancies. The most pronounced histological changes indicative of placental dysfunction were observed in cases in which COVID-19 was experienced during the second and third trimesters. In the placentas of convalescents at term, there was a statistically significant increase in the expression of the hypoxia markers HIF-1α and EPO compared to the control group. Additionally, a statistically significant increase in the apoptosis marker Caspase-3 was noted in the placentas of convalescents who experienced COVID-19 during the first and second trimesters.

Conclusion: Favorable perinatal outcomes were observed in convalescents with term pregnancies, regardless of the trimester in which the disease first manifested. However, pronounced histological and immunohistochemical changes in the placenta suggest the presence of placental insufficiency. Therefore, it is advisable to closely monitor this cohort of newborns from infancy to implement timely measures aimed at reducing the risk of potential long-term consequences.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Ella Kazachkova

South Ural State Medical University

Email: lyudalyn@mail.ru
ORCID iD: 0000-0002-1672-7058

Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology

Ресей, 64, Worowski St., Chelyabinsk, 454000

Ekaterina Voropaeva

South Ural State Medical University; Regional Perinatal Center

Email: lyudalyn@mail.ru
ORCID iD: 0000-0003-0800-3380

Dr. Med. Sci., Professor at the Department of Pathological Anatomy and Forensic Medicine; Chief Physician

Ресей, 64, Worowski St., Chelyabinsk, 454000; Bldg. 12, 70, Worowski St., Chelyabinsk, 454141

Lyudmila Ishchenko

South Ural State Medical University; Regional Clinical Hospital No. 2

Хат алмасуға жауапты Автор.
Email: lyudalyn@mail.ru
ORCID iD: 0000-0002-9405-0134

PhD, Associate Professor at the Department of Obstetrics and Gynecology; Obstetrician-Gynecologist

Ресей, 64, Worowski St., Chelyabinsk, 454000; 18, Gagarin St., Chelyabinsk, 454010

Evgeny Kazachkov

South Ural State Medical University

Email: lyudalyn@mail.ru
ORCID iD: 0000-0002-4512-3421

Dr. Med. Sci., Professor, Head of the Department of Pathological Anatomy and Forensic Medicine

Ресей, 64, Worowski St., Chelyabinsk, 454000

Anna Kholopova

South Ural State Medical University

Email: lyudalyn@mail.ru
ORCID iD: 0000-0001-5559-0069

PhD Student at the Department of Pathological Anatomy and Forensic Medicine

Ресей, 64, Worowski St., Chelyabinsk, 454000

Alexandra Zatvornitskaya

South Ural State Medical University

Email: lyudalyn@mail.ru
ORCID iD: 0000-0002-9245-3749

PhD, Teaching Assistant at the Department of Pathological Anatomy and Forensic Medicine

Ресей, 64, Worowski St., Chelyabinsk, 454000

Tatiana Shamaeva

South Ural State Medical University

Email: lyudalyn@mail.ru
ORCID iD: 0000-0001-6327-2685

PhD, Associate Professor at the Department of Mathematics, Medical Informatics, Informatics and Statistics

Ресей, 64, Worowski St., Chelyabinsk, 454000

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