Immune reactions in pregnant women with gestosis

The immunity system and its impact of infusion therapy were studied in pregnant women with gestosis. One hundred and ninety-three pregnant women with mild (MiG), moderate (MoG), and severe (SG) gestosis were examined. In gestosis, the immune system undergoes considerable changes as compared in normal pregnancy. In the pregnant women with gestosis, immune system dysfunction is characterized by leukocytosis (in MiG and MoG) and by leucopenia (in SG), by relative (MiG, MoG, and SG) and absolute (SG) lymphopenia; cellular immunodeficiency (absolute and relative T lymphocytopenia and increased leuko-T-index (MiG and MoG) and higher T/B lymphocyte ratio); impaired theophylline-susceptible/theophylline-resistant lymphocyte ratio towards the latter increase; relative and absolute neutrophilosis (MiG and MoG) and neutrophilopenia (SG); a marked activation of neutrophilic granulocytes (increased NCT test); enhanced activity of phagocytosis; elevated levels of IgM and IgA, and reduced IgG. Combined therapy exerts an immunomodulating impact in pregnant women. Inclusion of hydroxyethylated starch preparations (6 and 10% Refortan solutions) into the combined therapy of gestosis promotes a more effective correction of immune dysfunctions in pregnant women with gestosis and stabilization of their immune status.

pregnancy, gestosis, therapy, immune system