THE VAGINAL BIOCENOSIS IN THE USE OF MICRONIZED PROGESTERONE

Objective. To evaluate vaginal microbiocenosis in the use of micronized progesterone in reproductive age women. Subjects and methods. Thirty reproductive age women were examined. These included 10 women aged 21—27 years, who used vaginally micronized progesterone (utrogestan) 200 mg overnight on the 16-th to 25-th days of a menstrual cycle for 3 months (Group 1); 10 women aged 23—26 years, who took urogestan orally by the same procedure (Group 2), and 10 women aged 22—27 women who received no hormonal support (a control group). Prior to and 3 months after micronized progesterone use, vaginal biocenosis was examined by polymerase chain reaction with the detection of its real-time results, by applying Femoflor reagents. Results. The vaginal use of micronized progesterone did not differ from its oral use in effects on microbiocenosis; with the use of micronized progesterone, the total number of bacteria showed a preponderance of lactobacteria and the type of biocenosis was normocenosis or relative normocenosis. Conclusion. There was no deterioration in the vaginal microflora when micronized progesterone (utrogestan) was given via any (oral or vaginal) route. But by taking into account the fact that the study was conducted on a small group of women, it is necessary to continue a follow-up and to examine women using micronized progesterone vaginally.

micronized progesterone, vaginal microbiocenosis, Femoflor