THE SPECIFIC FEATURES OF THE THIRD TRIMESTER OF PREGNANCY AND LABOR IN OBESE PATIENTS

Objective. To study the specific features of the third trimester of pregnancy and labor and placental morphological changes in obese patients. Subjects and methods. A prospective cohort study was made in 100 patients in 2009 to 2011, who were divided into 3 groups according to the degree of obesity. Results. Irrespective of the degree of obesity, all the women developed metabolic syndrome. Regardless of the magnitude of obesity in the third trimester, every two pregnant women developed preeclampsia; every three women were at risk for preterm labor. As compared to first-degree obesity women, third-degree obesity patients were diagnosed as having chronic fetal hypoxia, amniotic fluid aspiration, and hypoxically ischemic lesion of the fetal central nervous system 3.5, 6, and 13 times more frequently, respectively. Placental histological study showed a preponderance of angiogenesis without vascular branching, as well as more evident vascular endothelial growth factor expression in the villous capillary endothelium and extravillous trophoblast.

VEGF, obesity, placenta, labor, neonatal infant, vascular endothelial growth factor