The species composition of lactobacilli in nonspecific vaginitis and bacterial vaginosis and its impact on local immunity


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Resumo

Objective. To study the species and quantitative composition of lactobacilli in women with nonspecific vaginitis and bacterial vaginosis and to evaluate its impact on local vaginal immunity. Subject and methods. Real-time polymerase chain reaction was used to examine 377 reproductive-aged women: 157patients with nonspecific vaginitis, 46 with bacterial vaginosis, and 174 apparently healthy women. Results. The lactoflora was shown to most frequently contain 4 Lactobacillus species: L. crispatus, L. iners, L. jensenii, and L. gasseri. In the control group, the lactoflora displayed a preponderance of L. crispatus. Nonspecific vaginitis and bacterial vaginosis were accompanied as part of the lactoflora by the higher percentage of L. iners and L.gasseri, respectively. The predominance of L. iners affected local immunity. Conclusion. The larger number of L. iners and L. gasseri as part of the lactoflora was associated with vaginitis of varying etiology and bacterial vaginosis.

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Sobre autores

O. Burmenskaya

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: bourmenska@mail.ru
PhD, Researcher

G. Bayramiva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: bayramova@mail.ru
MD, Clinic supervisor

O. Nepsha

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: o_nepsha@oparina4.ru
PhD, Researcher

D. Trofimov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: d.troflmov@dna-tech.ru
DSc, head of the laboratory molecular genetical methods

V. Muravyeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: v_muravieva@oparina4.ru
PhD, Researcher

P. Abakarova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: abakarova2002@mail.ru
MD, Researcher

D. Strelchenko

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: str_38l2@mail.ru
resident

V. Kryazheva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: salvaje@mail.ru
resident

G. Sukhikh

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru
MD, PhD, Professor

Bibliografia

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  3. Foster L.M., Tompkins T.A., Dahl W.J. A comprehensive post-market review of studies on a probiotic product containing Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011. Benef. Microbes. 2011; 2(4): 319-34.
  4. Yan D.H., Lü Z., Su J.R. Comparison of main Lactobacillus species between healthy women and women with bacterial vaginosis. Chin. Med. J. (Engl.). 2009; 122(22): 2748-51.
  5. Ravel J., Gajer P., Abdo Z., Schneider G.M., Koenig S.S., McCulle S.L. et al. Vaginal microbiome of reproductive-age women. Proc. Natl. Acad. Sci. USA. 2011; 108(Suppl. 1): 4680-7.
  6. Antonio M.A., Rabe L.K., Hillier S.L. Colonization of the rectum by Lactobacillus species and decreased risk of bacterial vaginosis. J. Infect. Dis. 2005; 192: 394-8.
  7. Rampersaud R., Planet PJ., Randis T.M., Kulkarni R., Aguilar J.L., Lehrer R.I., Ratner A.J. Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners. J. Bacteriol. 2011; 193(5): 1034-41.
  8. Vallor A.C., Antonio M.A.D., Hawes S.E., Hillier S.L. Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli: role of hydrogen peroxide production. J. Infect. Dis. 2001; 184(11): 1431-6.

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