ANTIANEMIC DRUGS IN THE COMBINATION TREATMENT OF SMALL PELVIC INFLAMMATORY DISEASES

Objective. To provide a pathogenetic rationale for the use of the iron preparation sorbifer durules to treat small pelvic inflammatory diseases (SPID) in relation to the processes of free radical oxidation. Subjects and methods. Reproductive-aged women who formed a control group of donors and a study group of patients with SPID were examined. Serum iron levels were colorimetrically determined using a Cobas Integra automated biochemical analyzer. Transferrin and ferritin concentrations were immunoturbidimetrically estimated with the same analyzer. A RANDOX test system was applied to determine the plasma total antioxidant status. Hemoglobin levels were measured using a Sysmex KX-21N hematological analyzer. IL-4, IL-8, TNF-a, INF-a, INF-y, and neopterin were analyzed by a competitive enzyme immunoassay employing a Multiskan Ascent semiautomated vertical photometer (Thermo Electron). Results. The significant decrease in the levels of serum iron, hemoglobin, and transferrin as the manifestations of endogenous intoxication syndrome become severe and blood loss is absent confirms that this cohort of patients develops anemia of inflammation. Conclusion. The findings suggest that there is a reduction in the level of serum iron and its depot concentration in SPID, which calls for correction with sorbifer durules.

anemia, small pelvic inflammatory diseases, pregnancy, free radical oxidation, sorbifer durules