SYNTHETIC GENISTEIN IN ACTIVE FORM FOR THE THERAPY OF MENOPAUSAL SYNDROME
- Autores: Lavrova L.V.1, Konovalov V.A.2, Levochkina L.N.1, Kopeykina E.A.1, Dyagileva N.I.1, Kuznetsova I.V.3
-
Afiliações:
- Women's Health Clinic, Ryazan Regional Clinical Hospital
- Academician I.P. Pavlov Ryazan State Medical University, Ministry of Health of Russia
- I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
- Edição: Nº 2 (2015)
- Páginas: 87-93
- Seção: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247419
- ID: 247419
Citar
Texto integral
Acesso está concedido
Acesso é pago ou somente para assinantes
Resumo
Palavras-chave
Texto integral
Sobre autores
Larisa Lavrova
Women's Health Clinic, Ryazan Regional Clinical Hospital
Email: w.cons@rokb.ru
Head of Women’s Health Clinic Ryazan 390039, International str. 3A, Russia
Viktor Konovalov
Academician I.P. Pavlov Ryazan State Medical University, Ministry of Health of RussiaPhD in Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology Ryazan 390026, Vysokovoltnaya str. 9, Russia
Larisa Levochkina
Women's Health Clinic, Ryazan Regional Clinical Hospital
Email: w.cons@rokb.ru
obstetrician-gynecologist Ryazan 390039, International str. 3A, Russia
Elena Kopeykina
Women's Health Clinic, Ryazan Regional Clinical Hospital
Email: w.cons@rokb.ru
Head of Women’s Health Clinic Ryazan 390039, International str. 3A, Russia
Natalia Dyagileva
Women's Health Clinic, Ryazan Regional Clinical Hospital
Email: w.cons@rokb.ru
Head of Women’s Health Clinic Ryazan 390039, International str. 3A, Russia
Irina Kuznetsova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Email: ms.smith.ivk@gmail.com
MD, Professor, Senior Researcher, Research Department of Female Health Moscow 119991, Trubetskaya str. 8 bld. 2, Russia
Bibliografia
- Кулаков В.И., ред. Клинические рекомендации. Акушерство и гинекология. Вып. 2. М.: ГЭОТАР-Медиа; 2008. 560 с.
- Genazzani A.R., Gambacciani M., Simoncini T. Menopause and aging, quality of life and sexuality. Climacteric. 2007; 10(2): 88-96.
- Nelson H.D., Haney E., Humphrey L., Miller J., Nedrow A., Nicolaidis C. et al. Management of menopause-related symptoms. Evid. Rep. Technol. Assess. (Summ.). 2005; 120: 1-6.
- Maclennan A.H., Broadbent J.L., Lester S., Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst. Rev. 2004; (4): CD002978.
- Freedman R. Pathophysiology and treatment of menopausal hot flashes. Semin. Reprod. Med. 2005; 23(2): 117-25.
- Ohmichi M., Tasaka K, Kurachi H., Murata Y. Molecular mechanism of action of selective estrogen receptor modulator in target tissues. Endocr. J. 2005; 52(2): 161-7.
- Williamson-Hughes P.S., Flickinger B.D., Messina M.J., Empie M.W. Isoflavone supplements containing predominantly genistein reduce hot flash symptoms: a critical review of published studies. Menopause. 2006; 13: 831-9.
- Newton K.M., Reed S.D., LaCroix A.Z., Grothaus L.C., Ehrlich K., Guiltinan J. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann. Intern. Med. 2006; 145: 869-79.
- Geller S.E., Shulman L.P., van Breemen R.B., Banuvar S., Zhou Y., Epstein G. et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause. 2009; 16: 1156-66.
- Nelson H.D. Menopause. Lancet. 2008; 371: 760-70.
- Taku K., Melby M.K., Kronenberg F., Kurzer M.S., Messina M. Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials. Menopause. 2012; 19(7): 776-90.
- Crisafulli A., Marini H., Bitto A., Altavilla D., Squadrito G., Romeo A. et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause. 2004; 11(4): 400-4.
- Albertazzi P., Steel S.A., Bottazzi M. Effect of pure genistein on bone markers and hot flushes. Climacteric. 2005; 8: 371-9.
- D’Anna R., Cannata M.L., Atteritano M., Cancellieri F., Corrado F., Baviera G. et al. Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo-controlled study. Menopause. 2007; 14: 648-55.
- Evans M., Elliott J.G., Sharma P., Berman R., Guthrie N. The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: a multi-center, randomized, placebo-controlled study. Maturitas. 2011; 68(2): 189-96.
- Marini H., Bitto A., Altavilla D., Burnett B.P., Polito F., Di Stefano V. et al. Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J. Clin. Endocrinol. Metab. 2008; 93(12): 4787-96.