Analysis of proand antioxidant activity in the blood of women with different phenotypes of polycystic ovary syndrome and infertility


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Acesso é pago ou somente para assinantes

Resumo

Objective. To reveal the specific features of the process of lipid peroxidation in reproductive-aged women with different phenotypes of polycystic ovary syndrome (PCOS). Subjects and methods. Forty-eight reproductive-aged women with PCOS and infertility were examined and divided into 2 subgroups according to the availability of criteria: 1) classical phenotypes; 2) non-classical phenotypes. Infertile women without PCOS (n = 31) and healthy women (n = 28) were used as comparison groups. Results. There were statistically significant differences in the examined parameters between the patients with different phenotypes of PCOS. At the same time, in the phenotype subgroups versus the controls and the infertile women without PCOS, the changes were mainly compensatory: slightly decreased superoxide dismutase activity and α-tocopherol concentrations and elevated retinol levels in the classical phenotype group and reduced levels of end thiobarbituric acid-reacting products of lipid peroxidation, increased a-tocopherol concentrations, and lower glutathione levels in the non-classical phenotype subgroup. Conclusion. In general, in PCOS, and in its classic hyperandrogenic phenotypes in particular, the changes in the lipid peroxidation processes are adaptive in nature, which allows one to recommend a personalized approach to combination treatment of this category of patients.

Texto integral

Acesso é fechado

Sobre autores

Marina Darenskaya

Research Center of Family Health and Human Reproduction Problems

Email: marina_darenskaya@inbox.ru
doctor of biological sciences, leading researcher of the laboratory of pathophysiology

Sergei Kolesnikov

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
Academician of the Russian Academy of Sciences, leading researcher

Lyudmila Grebenkina

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
doctor of biological sciences, leading researcher of the laboratory of pathophysiology

Irina Danusevich

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
doctor of medical sciences, senior researcher of the laboratory of gynecological endocrinology

Lyudmila Lazareva

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
candidate of medical sciences, senior researcher of the laboratory of gynecological endocrinology

Yana Nadelyaeva

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
candidate of medical sciences, researcher of the laboratory of gynecological endocrinology

Zorikto Darzhaev

Republican Perinatal Center, Ulan-Ude

Email: iphr@sbamsr.irk.ru
candidate of medical sciences, head of Human planning and reproduction center

Olga Nikitina

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
candidate of biological sciences, researcher of the laboratory of pathophysiology

Tatiana Bazarova

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
researcher of the laboratory of gynecological endocrinology

Lubov Kolesnikova

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
member of Russian Academy of Sciences, professor, doctor of medical sciences, scientific director

Bibliografia

  1. Lizneva D., Suturina L., Walker W., Brakta S., Gavrilova-Jordan L., Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil. Steril. 2016; 106(1): 6-15.
  2. Azziz R., Carmina E., Dewailly D., Diamanti-Kandarakis E., Escobar-Morreale H.F., Futterweit W. et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil. Steril. 2009; 91(2): 456-88.
  3. Moran C., Arriaga M., Rodriguez G., Moran S. Obesity differentially affects phenotypes of polycystic ovary syndrome. Int. J. Endocrinol. 2012; 2012: 317241.
  4. Yildiz B.O., Bozdag G., Yapici Z., Esinler I., Yarali H. Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum. Reprod. 2012; 27(10): 3067-73.
  5. Azziz R., Dumesic D., Goodarzi M. Polycystic ovary syndrome: an ancient disorder? Fertil. Steril. 2011; 95(5): 1544-8.
  6. Mohamed-Hussein Z.A., Harun S. Construction of a polycystic ovarian syndrome (PCOS) pathway based on the interactions of PCOS-related proteins retrieved from bibliomic data. Theor. Biol. Med. Model. 2009; 6: 18-31.
  7. Pasquali R., Stener-Victorin E., Yildiz B., Duleba A., Hoeger K., Mason H. et al. PCOS Forum: research in polycystic ovary syndrome today and tomorrow. Clin. Endocrinol. (Oxford). 2011; 74(4): 424-33.
  8. Tarlatzis B., Fauser B., Legro R., Hoeger N., Pasquali R., Franks S. et al. Consensus on infertility treatment related to polycystic ovary syndrome. Hum. Reprod. 2008; 23(3): 462-77.
  9. Колесникова Л.И., Сутурина Л.В., Лабыгина A.B., Лещенко О.Я., Федоров Б.А., Шолохов Л.Ф., Сафроненко A.B., Лебедева Л.Н., Кузьменко Е.Т., Лазарева Л.М., Наделяева Я.Г. Нарушения репродуктивого здоровья и репродуктивного потенциала в современных условиях Восточной Сибири. Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук. 2007; 2: 41-3. [Kolesnikova L.I., Suturina L. V., Labygina A.B. Leshhenko O.Ja., Fedorov B.A., Sholohov L.F., Safronenko A.B., Lebedeva L.N., Kuz’menko E.T., Lazareva L.M., Nadeljaeva Ja.G. Disorders of reproductive health and reproductive potential in modern conditions of Eastern Siberia. Bjulleten’ VSNC SO RAMN. 2007; 2: 41-43. (in Russian)]
  10. Gonzßlez F. Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction. Steroids. 2012; 77(4): 300-5.
  11. Уварова В.Н., Хащенко Е.П. Синдром поликистозных яичников с позиции современных данных патогенеза. Репродуктивное здоровье детей и подростков. 2013; 5: 54-60. [Uvarova V.N., Hashhenko E.P. Polycystic Ovary Syndrome from the perspective of modern pathogenesis of data. Reproduktivnoe zdorovye detej i podrostkov. 2013; 5: 54-60. (in Russian)]
  12. Kolesnikova L.I., Darenskaya М.А., Grebenkina L.A., Labygina A.V., Suturina L.V., Dolgikh M.I., Shiphineeva T.I., Darzhaev Z.Yu., Tsyrenov T.B., Rinchindorzhieva M.P. Activity of lipid peroxidation in infertile women from different populations. Bull. Exp. Biol. Med. 2012; 154(2): 203-5.
  13. Murri M., Luque-Ramirez M., Insenser M., Ojeda-Ojeda M., Escobar-Morreale H.F. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Hum. Reprod. Update. 2013; 19(3): 268-88.
  14. Duleba A.J., Dokras A. Is PCOS an inflammatory process? Fertil. Steril. 2012; 97(1): 7-12.
  15. Aponte A., Agarwal A. Oxidative stress impact on the fertility of women with polycystic ovary syndrome. In: Agarwal A., Aziz N., Rizk B., eds. Studies on women’s health. Humana Press; 2012: 169-80.
  16. Меньщикова Е.Б., Зенков Н.К., Ланкин В.З., Бондарь И.А., Труфакин В.А. Окислительный стресс: патологические состояния и заболевания. Новосибирск: Арта; 2008. [Menshhikova E.B., Zenkov N.K., Lankin V.Z., Bondar’ I.A., Trufakin V.A. Oxidative stress: pathological conditions and diseases. Novosibirsk: Arta, 2008; 284 s. (in Russian)]
  17. Ших Е.В., Махова А.А. Роль аскорбиновой кислоты и токоферола в профилактике и лечении заболеваний с точки зрения доказательной медицины. Терапевтический архив. 2015; 87(4): 98-102. [Shih E.V., Mahova A.A. Role of ascorbic acid and tocopherol in the prevention and treatment of diseases from the perspective of evidence-based medicine. Terapevticheskij arhiv. 2015; 87(4): 98-102. (in Russian)]
  18. Сутурина Л.В., Попова Л.Н. Динамика клинических симптомов и коррекция антиоксидантной недостаточности у женщин с диффузной мастопатией при использовании растительного препарата мастодинон. Акушерство и гинекология. 2012; 8-1: 56-9. [Suturina L.V., Popova L.N. The time course of changes in the clinical symptoms of antioxidandt deficiency and its correction with the herbal agent mastodynon in women with diffuse mastopathy. Akusherstvo i ginekologija/Obstetrics and Gynecology. 2012; (8-1): 56-9. (in Russian)]
  19. Кузнецова И.В. Роль окислительного стресса и антиоксидантной защиты в репродукции человека. Акушерство и гинекология. 2016; 3: 11621. http://dx.doi.org/10.18565/aig.2016.3.116-121 [Kuznetsova I.V. Role of oxidative stress and antioxidant defense in human reproduction. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2016; (3): 116-21. (in Russian) http:// dx.doi.org/10.18565/aig.2016.3.116-121]
  20. Колесникова Л.И., Гребенкина Л.А., Даренская М.А., Власов Б.Я. Окислительный стресс как неспецифическое патогенетическое звено репродуктивных нарушений (Обзор). Бюллетень Сибирского отделения Российской академии медицинских наук. 2012; 32(1): 58-66. [Kolesnikova L.I., Grebenkina L.A., Darenskaja M.A., Vlasov B.Ja. Oxidative stress as a nonspecific pathogenetic link of reproductive disorders (Review). Bjulleten’ SO RAMN. 2012; 32(1): 58-66. (in Russian)]
  21. Morin-Papunen C.L., Duleba A.J., Bloigu A., Järvelin M., Saikku P., Pouta A. Chlamydia antibodies and self-reported symptoms of oligo-amenorrhea and hirsutism: A new etiologic factor in polycystic ovary syndrome? Fertil. Steril. 2010; 94(5): 1799-804.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar

Declaração de direitos autorais © Bionika Media, 2017

Este site utiliza cookies

Ao continuar usando nosso site, você concorda com o procedimento de cookies que mantêm o site funcionando normalmente.

Informação sobre cookies