Analysis of proand antioxidant activity in the blood of women with different phenotypes of polycystic ovary syndrome and infertility


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Abstract

Objective. To reveal the specific features of the process of lipid peroxidation in reproductive-aged women with different phenotypes of polycystic ovary syndrome (PCOS). Subjects and methods. Forty-eight reproductive-aged women with PCOS and infertility were examined and divided into 2 subgroups according to the availability of criteria: 1) classical phenotypes; 2) non-classical phenotypes. Infertile women without PCOS (n = 31) and healthy women (n = 28) were used as comparison groups. Results. There were statistically significant differences in the examined parameters between the patients with different phenotypes of PCOS. At the same time, in the phenotype subgroups versus the controls and the infertile women without PCOS, the changes were mainly compensatory: slightly decreased superoxide dismutase activity and α-tocopherol concentrations and elevated retinol levels in the classical phenotype group and reduced levels of end thiobarbituric acid-reacting products of lipid peroxidation, increased a-tocopherol concentrations, and lower glutathione levels in the non-classical phenotype subgroup. Conclusion. In general, in PCOS, and in its classic hyperandrogenic phenotypes in particular, the changes in the lipid peroxidation processes are adaptive in nature, which allows one to recommend a personalized approach to combination treatment of this category of patients.

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About the authors

Marina Alexandrovna Darenskaya

Research Center of Family Health and Human Reproduction Problems

Email: marina_darenskaya@inbox.ru
doctor of biological sciences, leading researcher of the laboratory of pathophysiology

Sergei Ivanovich Kolesnikov

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
Academician of the Russian Academy of Sciences, leading researcher

Lyudmila Anatoljevna Grebenkina

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
doctor of biological sciences, leading researcher of the laboratory of pathophysiology

Irina Nikolaevna Danusevich

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
doctor of medical sciences, senior researcher of the laboratory of gynecological endocrinology

Lyudmila Mikhaylovna Lazareva

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
candidate of medical sciences, senior researcher of the laboratory of gynecological endocrinology

Yana Gennadjevna Nadelyaeva

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
candidate of medical sciences, researcher of the laboratory of gynecological endocrinology

Zorikto Yurjevich Darzhaev

Republican Perinatal Center, Ulan-Ude

Email: iphr@sbamsr.irk.ru
candidate of medical sciences, head of Human planning and reproduction center

Olga Andreevna Nikitina

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
candidate of biological sciences, researcher of the laboratory of pathophysiology

Tatiana Alexandrovna Bazarova

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
researcher of the laboratory of gynecological endocrinology

Lubov Iljinichna Kolesnikova

Research Center of Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
member of Russian Academy of Sciences, professor, doctor of medical sciences, scientific director

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