Predictors of the efficacy of metformin in polycystic ovary syndrome
- Authors: Naidukova A.A1, Ananyev E.V1, Donnikov A.E.1, Chernukha G.E1
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Affiliations:
- Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Issue: No 11 (2017)
- Pages: 69-76
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248073
- DOI: https://doi.org/10.18565/aig.2017.11.69-76
- ID: 248073
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Abstract
Subjects and methods. The investigation enrolled 143 women (mean age, 26.4±4.6 years; mean body mass index, 23.8±4.8 kg/m2) with PCOS. All the patients were treated with metformin 1500 mg/day for 6 months. All the study participants were divided into two groups: 1) 70 (53.1%) patients with a complete response to therapy; 2) 48 (36.3%) patients unresponsive to metformin therapy. 14 (10.6%) patients with a partial response to therapy were excluded from analysis. A comprehensive examination, including pelvic organ ultrasonography, determination of the serum levels of androgens, anti-Müllerian hormone (AMH), luteinizing hormone (LH), and follicle-stimulating hormone, and a two-hour glucose tolerance test was carried out to estimate the concentrations of glucose and insulin at baseline and after 6 months of therapy. Results. The comparative analysis revealed the higher levels of AMH, total testosterone (TT), and the A/G index in the nonresponse group. The levels of AMH of less than 13.3 ng/ml, TT of 1.81 ng/ml, and A/G index of less than 0.9 can be considered prognostically favorable. After 6 months of metformin therapy, there were decreases in the level of androgens in Group 1 (p < 0.05) and in that of AMH in both groups. Conclusion. Comprehensive examination, including the assessment of the hormonal profile and body composition, is indicated before metformin therapy for PCOS. Metformin therapy responses can be predicted, by estimating the serum levels of TT, AMH, and A/G index, which allows optimization of management tactics for patients with PCOS.
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About the authors
A. A Naidukova
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: aleeshka@mail.ru
post-graduate student, Department of Gynecological Endocrinology
E. V Ananyev
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: new_vision@mail.ru
head of the 2nd maternity ward
Andrey Evgenyevich Donnikov
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: a_donnikov@oparina4.ru
PhD, senior staff scientist of laboratory of molecular genetic methods
G. E Chernukha
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: c-galina1@yandex.ru
head of the Department of Gynecological Endocrinology
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