The role of the soluble fms-like tyrosin kinase-1 / the placental growth factor ratio in the diagnostics of preeclampsia in physiological pregnancy and pregnancy after IVF
- Autores: Ivanets T.Y.1, Kan N.E.1, Tyutyunnik V.L.1, Bezzubenko Y.V.1, Ibragimov R.R.1
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Afiliações:
- Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Edição: Nº 3 (2018)
- Páginas: 37-42
- Seção: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248158
- DOI: https://doi.org/10.18565/aig.2018.3.37-42
- ID: 248158
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Resumo
Objective. To compare PlGF, sFlt-1 concentrations reference ranges and sFlt-1/PlGF ratio in normal pregnancies and pregnancies after IVF and to reveal special features of these markers synthesis in pregnancies complicated by preeclampsia depending on the severity of the disease. Subject and methods. 547 pregnant women were enrolled in the study. Control group included 347 pregnant women with normal pregnancies. Study group included 148 women with pregnancies complicated by preeclampsia, 56 pregnant women had mild preeclampsia, 92 pregnant women had severe preeclampsia. We studied 25 patients with uncomplicated pregnancies after IVF for preeclampsia markers comparative analysis in normal pregnancies and pregnancies after IVF. Results. We obtained reference values of placental growth factor and soluble fms-like tyrosine kinase-1 and their ratio during normal pregnancy from 11-40 week of pregnancy. 90% of the values were within reference intervals for spontaneous uncomplicated pregnancy. The level of placental growth factor was lower the median value in 85% of all cases of pregnancies after IVF regardless of gestational age. Whereas the level of soluble fms-like tyrosine kinase-1 and sFlt-1/PlGF ratio were comparable to the levels of these markers in normal pregnancies. We revealed that sFlt-1/PlGF ratio is a significant marker of preeclampsia severity. Conclusion. This study showed feasibility of the use of investigated markers both in spontaneous pregnancies and pregnancies after IVF without restriction. Moreover, we revealed sFlt-1/PlGF ratio diagnostic value in preeclampsia severity assessment. The obtained results are of clinical importance, since they allow us to recommend the wide use of these markers in clinical practice for preeclampsia diagnosis and prediction to reduce obstetric complications rate and to improve perinatal outcomes.
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Sobre autores
Tatiana Ivanets
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: t_ivanets@oparina4.ru
the head of the clinical laboratory
Natalia Kan
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: kan-med@mail.ru
PhD, MD, the head of the obstetric department
Victor Tyutyunnik
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: tioutiounnik@mail.ru
PhD, MD, the head of the obstetric physiological department
Yulia Bezzubenko
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: j_bezzubenko@mail.ru
doctor for clinical laboratory diagnostics of the clinical laboratory
Ruslan Ibragimov
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: r_ibragimov@oparina4.ru
specialist in automated systems of protection
Bibliografia
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