Impact of noninvasive respiratory therapy in pregnant women with early severe preeclampsia on the levels of preeclampsia markers and mitochondrial DAMPs


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Resumo

Objective. To evaluate the clinical efficiency of continuous positive airway pressure (CPAP) therapy in the treatment of early severe preeclampsia according to clinical and laboratory findings and mitochondrial damage-associated molecular pattern (DAMP) levels. Material and methods. Blood biochemical tests were carried out to measure laboratory parameters (ALT, AST, AP, and LDH) and general urinalysis was used to identify proteinuria (PU) in women with severe preeclampsia before and after CPAP therapy. Microvesicle fractions were obtained from the plasma of female patients by differential centrifugation. The levels of L-ОРАБ and pre-TFAM were determined by chemiluminescent Western blotting. Results. A significant decrease was found in the level of placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), ALT, and PU indicators after one CPAP therapy cycle in patients with early severe preeclampsia. There was also a decline in the content of L-OPA1, a probable prognostic marker for severe preeclampsia. Conclusion. The efficiency of CPAP therapy is confirmed by a decrease in the values of key clinical markers for preeclampsia, including the mtDAMP marker L-OPA1.

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Sobre autores

Tatiana Skovorodina

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov

Email: t_skovorodina@oparina4.ru
graduate student

Polina Vishnyakova

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov

Email: p_vishnyakova@oparina4.ru
Researcher, Laboratory of Mitochondrial Medicine

Daria Tsvirkun

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov

Email: darunyat@gmail.com
Senior Researcher, Laboratory of Mitochondrial Medicine

Roman Shmakov

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov

Email: r_shmakov@oparina4.ru
Professor, Doctor of Medical Sciences, Chief Physician

Mikhail Vysokikh

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov

Email: m_vysokikh@oparina4.ru
Ph.D., head. laboratory of mitochondrial medicine

Konstantin Kalachin

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov

Email: k_kalachin@oparina4.ru
doctor of the anesthesiology and intensive care unit

Aleksey Pyregov

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov

Email: a_pyregov@oparina4.ru
MD, Head of the Department of Anesthesiology and Resuscitation

Bibliografia

  1. Issa F.G., Berthon-Jones M., Eves L. Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet. 1981; 1(8225): 862-5.
  2. Sahota P.K., Jain S.S., Dhand R. Sleep disorders in pregnancy. Curr. Opin. Pulm. Med. 2003; 9(6): 477-83.
  3. Романова В.В., Горшинова В.К., Шмаков Р.Г., Шифман Е.М. Роль сонного апноэ в развитии преэклампсии. Акушерство и гинекология. 2012; 4-2: 4-9.
  4. Kapsimalis F., Kryger M. Obstructive sleep apnea in pregnancy. Sleep Med. Clin. 2007; 2: 603-13.
  5. Gozal D., Kheirandish-Gozal L. Cardiovascular morbidity in obstructive sleep apnea oxidative stress, inflammation, and much more. Am. J. Respir. Crit. Care Med. 2008; 177(4): 369-75.
  6. Ходжаева З.С., Коган Е.А., Клименченко Н.И., Акатьева А.С., Сафонова А.Д., Холин А.М., Вавина О.В., Сухих Г.Т. Клинико-патогенетические особенности ранней и поздней преэклампсии. Акушерство и гинекология. 2015; 1: 12-7.
  7. Visasiri Tantrakul, Jee Hyun Kim, Christian Guilleminault. Continuous positive airway pressure as a potential treatment for preeclampsia. Open Sleep J. 2013; 6(Suppl. 1: M5): 37-43.
  8. Poyares D., Guilleminault C., Hachul H., Fujita L., Takaoka S., Tufik S., Sass N. Preeclampsia and nasal CPAP: Part 2. Hypertension during pregnancy, chronics noring, and early nasal CPAP intervention. Sleep Med. 2007; 9(1): 15-21.
  9. Tong M., Johansson C., Xiao F., Stone P.R., James J.L., Chen Q. et al. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Sci. Rep. 2017; 7(1): 16556.
  10. Wenceslau C.F., McCarthy C.G., Szasz T., Spitler K., Goulopoulou S., Webb R.C. Mitochondrial damage-associated molecular patterns and vascular function. Eur. Heart J. 2014; 35(18): 1172-7.
  11. Hopps E., Caimi G. Obstructive sleep apnea syndrome: links betwen pathophysiology and cardiovascular complications. Clin. Invest. Med. 2015; 38(6): E362-70.
  12. Сковородина Т.В., Вишнякова П.А., Шмаков Р.Г., Высоких М.Ю. Роль митохондриальных маркеров в патогенезе преэклампсии и оценка эффективности респираторной терапии в лечении преэклампсии. Акушерство и гинекология. 2017; 6: 5-9. http://dx.doi.org/10.18565/aig.2017.6.5-9
  13. Hoffmann J., Ossada V., Weber M., Stepan H. An intermediate sFlt-1/PlGF ratio indicates an increased risk for adverse pregnancy outcome. Pregnancy Hypertens. 2017;10: 165-70.
  14. Сковородина Т.В., Вишнякова П.А., Цвиркун Д.В., Шмаков Р.Г., Высоких М.Ю. Роль митохондриальных молекул, ассоциированных с повреждением, в манифестации гипертензивных осложнений беременности. Акушерство и гинекология. 2017; 12: 84-8. https://dx.doi.org/10.18565/aig.2017.12.84-88

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