Plasma levels of transforming growth factor p isoforms in women with preeclampsia


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Objective. To investigate the role of transforming growth factor (TGF) -β in the development of preeclampsia. Material and methods. The study comprised 30 women with preeclampsia and 20 women with uncomplicated pregnancy. Plasma concentrations of TGF-β isoforms (TGF-β1, TGF-β2, TGF-β3) were determined by a standard test system on a Bio-Plex 200 analyzer (Bio-Rad, USA) with subsequent processing using Bio-Plex Manager 6.0 Properties. Results. Plasma levels of TGF-β3 in women with preeclampsia were lower than in the control subjects (p = 0.034). Women with and without PE had similar plasma levels of TGF-β1 and TGF-β2 isoforms. Patients with early preeclampsia had significantly lower plasma levels of TGF-β3 than women in the control group [(38.71 (8.00) vs. 48.42 (10.60), p = 0.008]. Conclusion. The study findings suggest that the expression of TGF-β3 may be considered as a promising early biomarker for preeclampsia.

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Sobre autores

Valentina Vtorushina

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: vtorushina@inbox.ru
PhD, doctor of the highest category of the Clinical Immunology

Daria Kharchenko

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: drkharchenko@mail.ru
postgraduate student

Lyubov Krechetova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: l_krechetova@oparina4.ru
PhD, head of the Clinical Immunology Laboratory

Evgeny Astashkin

I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)

Email: ast-med@mail.ru
MD, professor of the Department of Pathology

Natalia Kan

Chief Doctor of the Perinatal Center EMC

Email: kan-med@mail.ru
MD, professor

Bibliografia

  1. Серов В.Н., Баранов И.И., Пекарев О.Г., Пырегов А.В., Тютюнник В.Л., Шмаков Р.Г. Неотложная помощь в акушерстве и гинекологии. М.: ГЭОТАР-Медиа; 2017. 240с.
  2. Сидорова И.С., Никитина Н.А., Унанян А.Л. Преэклампсия и снижение материнской смертности в России. Акушерство и гинекология. 2018; 1: 107-12.
  3. Кетлинский С.А., Симбирцев А.С. Цитокины. М.: Фолиант; 2008: 369-78.
  4. Gutter S. Role of the syncytium in placenta-mediated complications of preeclampsia. Thromb. Res. 2009; 124(4): 389-92. doi: 10.1016/j. thromres.2009.05.016.
  5. Li X., Shen L., Tan H. Polymorphisms and plasma level of transforming growth factor-Beta 1 and risk for preeclampsia: a systematic review. PLoS One. 2014; 9(5): e97230. doi: 10.1371/journal.pone.0097230. eCollection 2014.
  6. Prunier C., Baker D., Ten Dijke P., Ritsma L. TGF-ß family signaling pathways in cellular dormancy. Trends Cancer. 2019; 5(1): 66-78. doi: 10.1016/j. trecan.2018.10.010.
  7. Cantelli G., Crosas-Molist E., Georgouli M., Sanz-Moreno V. TGF-ß -induced transcription in cancer. Semin. Cancer Biol. 2017; 42: 60-9. doi: 10.1016/j. semcancer.2016.08.009.
  8. Zhong J., Liu C., Zhang Q.H., Chen L., Shen Y.Y., Chen Y.J. et al. TGF-β1 induces HMGA1 expression: The role of HMGA1 in thyroid cancer proliferation and invasion. Int. J. Oncol. 2017; 50(5): 1567-78. doi: 10.3892/ ijo.2017.3958.
  9. Lee S.B., Wong A.P., Kanasaki K., Xu Y., Shenoy V.K., McElrath T.F. et al. Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions. Am. J. Pathol. 2010; 176(2): 710-20. doi: 10.2353/ajpath.2010.090513.
  10. Ходжаева З.С., Холин А.М., Вихляева Е.М. Ранняя и поздняя преэклампсия: парадигмы патобиологии и клиническая практика. Акушерство и гинекология. 2013; 10: 4-11.
  11. Li X., Tan H., Chen M., Zhou S. Transforming growth factor beta 1 related gene polymorphisms in gestational hypertension and preeclampsia: A case-control candidate gene association study. Pregnancy Hypertens. 2018; 12: 155-60. doi: 10.1016/j.preghy.2017.11.010.
  12. Darmochwal-Kolarz D., Michalak M., Kolarz B., Przegalinska-Kalamucka M., Bojarska-Junak A., Sliwa D., Oleszczuk J. The role of interleukin-17, interleukin-23, and transforming growth factor-ß in pregnancy complicated by placental insufficiency. Biomed. Res. Int. 2017; 2017: 6904325. doi: 10.1155/2017/6904325.
  13. Xu Y.T., Shen M.H., Jin A.Y., Li H., Zhu R. Maternal circulating levels of transforming growth factor-ß superfamily and its soluble receptors in hypertensive disorders of pregnancy. Int. J. Gynaecol. Obstet. 2017; 137(3): 246-52. doi: 10.1002/ijgo.12142.
  14. Zhang J., Dunk C.E., Shyntova O., Caniggia I., Lye S.J. TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia. EBioMedicine. 2019; 39: 531-9. doi: 10.1016/j.ebiom.2018.12.015.
  15. Caniggia I., Grisaru-Gravnosky S., Kuliszewsky M., Post M., Lye S.J. Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies. J. Clin. Invest. 1999; 103(12): 1641-50. doi: 10.1172/ JCI6380
  16. Kar M. Role of biomarkers in early detection of preeclampsia. J. Clin. Diagn. Res. 2014; 8(4): BE01-4. doi: 10.7860/JCDR/2014/ 7969.4261.
  17. Yi Y., Cheng J.C., Klausen C., Leung PC.K. TGF-ß1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2. Placenta. 2018; 68: 44-51. doi: 10.1016/j.placenta.2018.06.313.

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