Plasma levels of transforming growth factor p isoforms in women with preeclampsia
- Authors: Vtorushina V.V.1, Kharchenko D.K.1, Krechetova L.V.1, Astashkin E.I.2, Kan N.E.3
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Affiliations:
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
- I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)
- Chief Doctor of the Perinatal Center EMC
- Issue: No 2 (2019)
- Pages: 68-73
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248429
- DOI: https://doi.org/10.18565/aig.2019.2.68-73
- ID: 248429
Cite item
Open Access
Access granted
Abstract
Objective. To investigate the role of transforming growth factor (TGF) -β in the development of preeclampsia. Material and methods. The study comprised 30 women with preeclampsia and 20 women with uncomplicated pregnancy. Plasma concentrations of TGF-β isoforms (TGF-β1, TGF-β2, TGF-β3) were determined by a standard test system on a Bio-Plex 200 analyzer (Bio-Rad, USA) with subsequent processing using Bio-Plex Manager 6.0 Properties. Results. Plasma levels of TGF-β3 in women with preeclampsia were lower than in the control subjects (p = 0.034). Women with and without PE had similar plasma levels of TGF-β1 and TGF-β2 isoforms. Patients with early preeclampsia had significantly lower plasma levels of TGF-β3 than women in the control group [(38.71 (8.00) vs. 48.42 (10.60), p = 0.008]. Conclusion. The study findings suggest that the expression of TGF-β3 may be considered as a promising early biomarker for preeclampsia.
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About the authors
Valentina V. Vtorushina
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: vtorushina@inbox.ru
PhD, doctor of the highest category of the Clinical Immunology
Daria K. Kharchenko
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: drkharchenko@mail.ru
postgraduate student
Lyubov V. Krechetova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: l_krechetova@oparina4.ru
PhD, head of the Clinical Immunology Laboratory
Evgeny I. Astashkin
I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)
Email: ast-med@mail.ru
MD, professor of the Department of Pathology
Natalia E. Kan
Chief Doctor of the Perinatal Center EMC
Email: kan-med@mail.ru
MD, professor
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