Immune mechanisms of regulating the growth of uterine leiomyoma


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Resumo

Objective. To identify the characteristics of the expression of natural cytotoxicity receptors (NCRs), a family of NCRs by natural killer (NK) cells that invade the endometrium that is located in the projection of the myomatous node, as well as the features of collagen synthesis in various types of uterine leiomyoma. Subjects and methods. The expression of NCRs by NKcells was determined in 51 women with symptomatic uterine leiomyoma in the endometrium. Ki67and COL1A1 mRNA levels were measured in myomatous node tissue. Results. The endometrium located in the projection of the myomatous node shows changes in the expression of NCRs depending on the intensity of proliferative processes. The increased collagen synthesis in the small myomatous nodes is associated with minimal proliferative activity. Conclusion. NK cells affect tumor growth processes, inhibiting the proliferation of leiomyocytes, by indirectly enhancing tissue collagen synthesis. The shift in the activation of endometrial NK cells may be one of the mechanisms of reproductive dysfunction in uterine fibroids.

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Sobre autores

Anna Malyshkina

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: ivniimid@inbox.ru
doctor of medical sciences, Professor, Director

Daria Voskresenskaya

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: kasyanikdariakis@mail.ru
graduate student of the laboratory of clinical immunology

Dmitry Voronin

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: niimid.immune@mail.ru
candidate of biological sciences, senior researcher of the laboratory of clinical immunology

Yulia Antsiferova

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: niimid.immune@mail.ru
doctor of biological sciences, leading scientific researcher of the laboratory of clinical immunology

Natalia Sotnikova

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: niimid.immune@mail.ru
doctor of medical sciences, Professor, head of the laboratory of clinical immunology

Daria Malyshkina

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: nidsumi@mail.ru
MD, student

Bibliografia

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