Placental vessel thrombosis as a cause of antenatal fetal death in pregnant women with novel coronavirus infection


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The paper describes 2 cases of antenatal fetal death in pregnant patients with mild and moderate COVID-19 and a familial history of non-developing pregnancies that occurred in the third wave of the epidemic process. One patient was recorded to have antenatal fetal death that occurred at 37-38 weeks’ gestation with a birth weight of 2670 g and the other patient had that at 23-24 weeks’ gestation with a birth weight of 520 g in the late stages of the disease (days 9 and 13, respectively). These patients are described to have placental morphological alterations; there was a preponderance of the signs of severe maternal vascular malperfusion as thrombosis in the intervillous space with massive fibrin deposits; large hematomas and infarcts, extensive numerous areas of fibrinoid villous agglutination and an inflammatory reaction. At the same time, the standard methods were used to detect viral RNA in the tissues of the placenta, fetal lungs, and maternal nasopharynx. Conclusion: The analysis of each antenatal fetal death case in pregnant patients with COVID-19 is the basis for the formation of recommendations for the prevention of perinatal complications

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Sobre autores

Galina Malgina

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: galinamalgina@mailru
Dr. Med. Sci., Director

Anastasia Grishkina

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: xumukycm@mah.ru
PhD, Pathologist, Department of Immunology, Clinical Microbiology, Pathomorphology and Cytodiagnosis

Maria Dyakova

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: mariadakova40@mail.ru
Junior Researcher, PhD student

Svetlana Bychkova

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: simomm@mail.ru
PhD, Leading Researcher

Guzel Chistyakova

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: guzel@niiomm.ru
Dr. Med. Sci., Professor, Head of the Department of Immunology, Clinical Microbiology, Pathomorphology and Cytodiagnosis

Natalia Pepelyaeva

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: pepelyaevana@niiomm.ru
PhD, Head of the Department

Oksana Melkozerova

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: abolmed1@mailru
Dr. Med. Sci., Deputy Director for Science

Nadezhda Bashmakova

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: bashmakovanv@niiomm.ru
Dr. Med. Sci., Professor, Chief Researcher

Lyudmila Pestryaeva

Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia

Email: pestryaeval@yandex.ru
PhD (Bio), Head of the Department of Biochemical Research Methods

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