Non-developing pregnancy in the uterine scar after caesarean section: diagnostic difficulties

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Abstract

Background: The steady increase in the number of patients with a history of even one caesarean section leads to a rise in the frequency of such form of ectopic pregnancy, as pregnancy in the scar. The choice of the optimal organ-sparing treatment option for this category of patients depends on timely diagnosis. The formation of retrochorial hematoma that accompanies non-developing pregnancy in the scar in the early stages significantly complicates the diagnosis.

Case report: The paper describes a clinical case of a reproductive-aged patient, in whom a long episode of menometrorrhagia ended with the formation of a round mass up to 8 cm in diameter in the area of the scar after cesarean section at the uterine isthmus. Erroneously diagnosed incomplete abortion during uterine pregnancy and uterine fibroids served as a reason for uterine curettage complicated by massive blood loss. The final diagnosis was established after pathological mass excision and metroplasty.

Conclusion: A pathological uterine mass localized in the scar area after cesarean section, which is suddenly detected during abnormal uterine bleeding, requires the exclusion of pregnancy in this area. Correct diagnosis of non-developing pregnancy in the scar is the key to successful organ-sparing surgery.

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About the authors

Mark A. Kurtser

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: m.kurtser@mcclinics.ru
ORCID iD: 0000-0003-0175-1968

MD, PhD, Professor, Member of the Russian Academy of Sciences, Head of Department of Obstetrics and Gynecology, Pediatric Faculty

Russian Federation, Moscow

Irina Yu. Breslav

MD GROUP Clinical Hospital, MD PROJECT 2000

Author for correspondence.
Email: irina_breslav@mail.ru
ORCID iD: 0000-0002-0245-4968

MD, PhD, Head of the Department of Pathology of Pregnancy

Russian Federation, Moscow

Marina L. Kolotilova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: Kolotilovaml@hotmail.com
ORCID iD: 0000-0001-7270-8671

MD, PhD, Professor at Human Pathology Department, Institute of Biodesign and Modeling of Complex Systems

Russian Federation, Moscow

Olga P. Barykina

MD GROUP Clinical Hospital, MD PROJECT 2000

Email: medslovar@mail.ru

Head of the Department of Pathology, Pathologist

Russian Federation, Moscow

Nikolay V. Scriabin

MD GROUP Clinical Hospital, MD PROJECT 2000

Email: hranitelkr@mail.ru
ORCID iD: 0000-0001-8247-7563

Pathologist at the Department of Pathology

Russian Federation, Moscow

Olga N. Kurbatskaya

Lapino Clinical Hospital

Email: kuron682@gmail.com

MD, Head of the Department of Pathology of Pregnancy

Russian Federation, Moscow Region

References

  1. Ministry of Health of Russian Federation. Clinical guidelines. Ectopic (ectopic) pregnancy, 2021. (in Russian).
  2. Baranovskaya E.I. Ectopic ovum and heterotopic pregnancy. Topical issues of obstetrics and gynecology in Belarus. 2018; 4: 9-11. (in Russian).
  3. M.E. Shchepelev, T.V. Deripasko, A.A. Sidorova, E.G. Drandrova, E.V. Moskvichev, T.Yu. Clinical case of non-developing pregnancy in the uterine scar after caesarean section. Acta Medica Eurasica. 2021; 3: 26-34. (in Russian). https://dx.doi.org/10.47026/ 2413-4864-2021-3-26-34.
  4. Buyanova S.N., Shchukina N.A., Chechneva M.A., Puchkova N.V., Zemskova N.Yu., Torobaeva M.T. Pregnancy in the scar after caesarean section: the possibility of surgical correction. Russian Bulletin of the Obstetrician-Gynecologist. 2020; 20(6): 65-70. (in Russian). https://dx.doi.org/10.17116/rosakush20202006165.
  5. Zakharov I.S., Elgina S.I., Mozes V.G., Rudaeva E.V., Pachgin I.V., Rybnikov S.V. Ectopic pregnancy in the scar after caesarean section. Mother and Child in Kuzbass. 2020; 4: 88-91. (in Russian). https://dx.doi.org/10.24411/2686-7338-2020-10055.
  6. Timor-Tritsch I.E., Monteagudo A. Unforeseen consequences of the increasing rate of cesarean deliveres: early placenta accrete and cesarean scar pregnancy. A review. Am. J. Obstet. Gynecol. 2012; 207(1): 14-29. https://dx.doi.org/ 10.1016/j.ajog.2012.03.007.

Supplementary files

Supplementary Files
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1. JATS XML
2. Figure 1. T2-weighted image, coronal plane. A knot of heterogeneous structure along the anterior wall of the uterus in the isthmus with a transition to the left rib, deforms the uterine cavity

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3. Figure 2. Gross specimen of the excised uterine wall: an irregularly shaped formation with an adjacent area of grayish tissue

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4. Figure 3. Thinned uterine wall, represented by a connective tissue (uterine scar), to which is adjacent a hematoma area that encloses necrotic chorionic villi in the form of "shadows". Hematoxylin-eosin staining, low magnification (x40)

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