Plasma levels of cell adhesion molecules in normal pregnancy and preeclampsia
- Autores: Shelekhin A.P.1, Baev O.R.2,1, Andreev Y.V.3, Sadekova A.A.2, Krasnyi A.M.2
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Afiliações:
- I.M. Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University)
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Health Department
- Edição: Nº 11 (2023)
- Páginas: 71-77
- Seção: Original Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/626070
- DOI: https://doi.org/10.18565/aig.2023.200
- ID: 626070
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Resumo
Objective: The objective of this study was to determine the levels of soluble forms of cell adhesion molecules (sVCAM-1, sICAM-1, sE-selectin, and sP-selectin) in the maternal blood of women with preeclampsia (PE) and compare them to levels in women with normal pregnancies, taking into account the severity and phenotype of PE.
Materials and methods: A prospective case-control study was conducted involving peripheral blood plasma samples collected from women with normal pregnancies (n=30) and preeclampsia (n=50). Multiplex assay was used to determine the concentrations of sVCAM-1, sICAM-1, sE-selectin, and sP-selectin.
Results: The concentration of sVCAM-1 in peripheral blood was significantly higher in women with preeclampsia than in those with uncomplicated pregnancies (p<0.001). Furthermore, sVCAM-1 levels were significantly higher in severe than in moderate preeclampsia (p=0.014). In addition, sVCAM-1 levels were higher in patients with early-onset than in those with late-onset preeclampsia. However, no statistically significant differences were observed in the levels of sICAM-1, sE-selectin, or sP-selectin.
Conclusion: Our study revealed increased sVCAM-1 levels in the peripheral blood of pregnant women with preeclampsia. This elevation correlates with the severity of the disease, suggesting the involvement of this molecule in the development of preeclampsia. The differences in sVCAM-1 levels between early- and late-onset preeclampsia suggest different pathogenic mechanisms underlying these two conditions.
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Sobre autores
Artemiy Shelekhin
I.M. Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University)
Autor responsável pela correspondência
Email: dr.shelekhin@gmail.com
ORCID ID: 0000-0002-7682-1329
postgraduate student
Rússia, MoscowOleg Baev
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University)
Email: o_baev@oparina4.ru
ORCID ID: 0000-0001-8572-1971
Dr. Med. Sci., Professor, Head of the 1st maternity, Professor at the Department of Obstetrics, Gynecology, Perinatology and Reproductology
Rússia, 117997, Moscow, Ac. Oparina str., 4, 119991, Moscow, Trubetskaya str., 8-2Yuliy Andreev
N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Health Department
Email: AndreevUV@sklif.mos.ru
ORCID ID: 0000-0001-8151-940X
PhD, Senior Researcher at the Department of Biotechnologies and Transfusiology
Rússia, 129090, Moscow, B. Sukharevskaya sqr., 3Alsu Sadekova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: sialsad@gmail.com
ORCID ID: 0000-0003-4726-7477
PhD, Senior Researcher at the Cytology Laboratory
Rússia, 119991, Moscow, Trubetskaya str., 8-2Alexey Krasnyi
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: a_krasnyi@oparina4.ru
ORCID ID: 0000-0001-7883-2702
PhD, Head of the Cytology Laboratory
Rússia, 119991, Moscow, Trubetskaya str., 8-2Bibliografia
- Министерство здравлоохранения Российской Федерации. Преэклампсия. Эклампсия. Отеки, протеинурия и гипертензивные расстройства во время беременности, в родах и послеродовом периоде. Клинические рекомендации. М.; 2021. [Ministry of Health of the Russian Federation. Preeclampsia. Eclampsia. Edema, proteinuria and hypertensive disorders during pregnancy, childbirth and the postpartum period. Clinical guidelines. Moscow; 2021 (in Russian)].
- Roberts J.M., Rich-Edwards J.W., McElrath T.F., Garmire L., Myatt L. Subtypes of preeclampsia: recognition and determining clinical usefulness. Hypertension. 2021; 77(5): 1430-41. https://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14781.
- Шелехин А.П., Баев О.Р., Красный А.М. Сравнение течения и исходов беременностей, осложненных гипертензивными расстройствами. Акушерство и гинекология. 2023; 1: 41-7. [Shelekhin A.P., Baev O.R., Krasnyi A.M. Comparison of the course and outcomes of pregnancies complicated by hypertensive disorders. Obstetrics and Gynecology. 2023;(1): 41-7. (in Russian)]. https://dx.doi.org/10.18565/aig.2022.248.
- Madazli R., Yuksel M.A., Imamoglu M., Tuten A., Oncul M., Aydin B., Demirayak G. Comparison of clinical and perinatal outcomes in early- and late-onset preeclampsia. Arch. Gynecol. Obstet. 2014;290(1):53-7. https://dx.doi.org/10.1007/s00404-014-3176-x.
- Robillard P.-Y., Dekker G., Scioscia M., Saito S. Progress in the understanding of the pathophysiology of immunologic maladaptation related to early-onset preeclampsia and metabolic syndrome related to late-onset preeclampsia. Am. J. Obstet. Gynecol. 2022;226(2):S867-75. https://dx.doi.org/10.1016/ j.ajog.2021.11.019.
- Redman C.W.G., Staff A.C., Roberts J.M. Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways. Am. J. Obstet. Gynecol. 2022;226(2):S907-27. https://dx.doi.org/10.1016/j.ajog.2020.09.047.
- Шелехин А.П., Баев О.Р., Садекова А.А., Кокоева Д.Н., Красный А.М. Особенности содержания Е-кадгерина в плазме крови и ткани плаценты при преэклампсии. Акушерство и гинекология. 2023; 3: 36-40. [Shelekhin A.P., Baev O.R., Sadekova A.A., Kokoeva D.N., Krasnyi A.M. The content of different forms of E-cadherin in blood plasma and placental tissue in preeclampsia. Obstetrics and Gynecology. 2023;(3): 36-40. (in Russian)]. https://dx.doi.org/10.18565/aig.2022.282.
- Baev O.R., Karapetian A.O., Nizyaeva N.V., Sadekova А.А., Krasniy A.M. Content of free fetal DNA in maternal blood and expression of DNA recognition receptors ZBP-1 in placental tissue in preeclampsia and preterm labor. Bull. Exp. Biol. Med. 2019;168(1):145-9. https://dx.doi.org/10.1007/ s10517-019-04665-z.
- Essick E., Sithu S., Dean W., D’Souza S. Pervanadate-induced shedding of the intercellular adhesion molecule (ICAM)-1 ectodomain is mediated by membrane type-1 matrix metalloproteinase (MT1-MMP). Mol. Cell Biochem. 2008;314(1-2):151-9. https://dx.doi.org/10.1007/s11010-008-9776-7.
- Зиганшина М.М., Кречетова Л.В., Ванько Л.В., Культербаева М.А., Соколян А.В., Сухих Г.Т. Динамика растворимых форм молекул клеточной адгезии при преэклампсии. Акушерство и гинекология. 2011;2:42-8. [Ziganshina M.M., Krechetova L.V., Vanko L.V., Kulterbayeva M.A., Sokolyan A.V., Sukhikh G.T. Time course of changes in the soluble forms of cell adhesion, molecules in preeclampsia. Obstetrics and Gynecology. 2011;(2):42-8 (in Russian)].
- Сидорова И.С., Никитина Н.А. Особенности патогенеза эндотелиоза при преэклампсии. Акушерство и гинекология. 2015;1:72-8. [Sidorova I.S., Nikitina N.A. Pathogenesis of endotheliosis in preeclampsia. Obstetrics and Gynecology. 2015;(1):72-8 (in Russian)].
- Chaiworapongsa T., Romero R., Yoshimatsu J., Espinoza J., Kim Y.M., Park K. et al. Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia. J. Matern. Neonatal. Med. 2002;12(1):19-27. https://dx.doi.org/10.1080/jmf.12.1.19.27.
- Farzadnia M., Ayatollahi H., Hasan-Zade M., Rahimi H.R. A comparative study of vascular cell adhesion molecule-1 and high-sensitive C-reactive protein in normal and preeclamptic pregnancies. Interv. Med. Appl. Sci. 2013;5(1):26-30. https://dx.doi.org/10.1556/imas.5.2013.1.5.
- Adu-Gyamfi E.A., Czika A., Gorleku P.N., Ullah A., Panhwar Z., Ruan L.-L. et al. The involvement of cell adhesion molecules, tight junctions, and gap junctions in human placentation. Reprod. Sci. 2021;28(2):305-20. https://dx.doi.org/10.1007/s43032-020-00364-7.
- Haram K., Mortensen J.H., Myking O., Magann E.F., Morrison J.C. The Role of oxidative stress, adhesion molecules and antioxidants in preeclampsia. Curr. Hypertens. Rev. 2019;15(2):105-12. doi:10.2174/ 1573402115666190119163942.
- Kornacki J., Wirstlein P., Wender-Ozegowska E. Markers of endothelial injury and dysfunction in early- and late-onset preeclampsia. Life (Basel). 2020;10(10):239. https://dx.doi.org/10.3390/life10100239.
- Docheva N., Romero R., Chaemsaithong P., Tarca A.L., Bhatti G., Pacora P. et al. The profiles of soluble adhesion molecules in the “great obstetrical syndromes”. J. Matern. Neonatal. Med. 2019;32(13):2113-36. https://dx.doi.org/10.1080/ 14767058.2018.1427058.
- Pasaribu H.P., Hariman H., Roeshadi R.H., Koh S.C. Soluble vascular cell adhesion molecule-1 and magnesium sulfate with nifedipine treatment in Indonesian women with severe pre-eclampsia. Interv. Med. Appl. Sci. 2016;8(3):97-102. https://dx.doi.org/10.1556/1646.8.2016.3.4.
- Kim S.Y., Ryu H.M., Yang J.H., Kim M.Y., Ahn H.K., Lim H.J. et al. Maternal serum levels of VCAM-1, ICAM-1 and E-selectin in preeclampsia. J. Korean Med. Sci. 2004;19(5):688-92. https://dx.doi.org/10.3346/jkms.2004.19.5.688.
- Liu B., Liu L., Cui S., Qi Y., Wang T. Expression and significance of microRNA-126 and VCAM-1 in placental tissues of women with early-onset preeclampsia. J. Obstet. Gynaecol. Res. 2021; 47(6): 2042-50. https://dx.doi.org/10.1111/jog.14732.
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