Characteristics of circadian regulation in patients with miscarriage

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The article presents the analysis of circadian regulation disorders contributing to miscarriage and complicating the course of pregnancy. The circadian system of the body provides regulation of the neuroendocrine-immune (NEIM) system, dynamic balance and the process of adaptation of the female body to the developing pregnancy, and fetal growth. The autonomous circadian regulation is formed in the fetus/embryo under the influence of endogenous and exogenous signals that carry information through the placenta during normal pregnancy. The transcription factor genes CLOCK/BMAL1, the light period genes Period 1-3/Cryptochrome 1-2 and their protein products play an important role in the process of circadian regulation. Mutations in genes regulating and controlling the “clock” are accompanied in experiment and clinic by the development of pathologic conditions followed by disruption of estrous cycles, failure of embryo implantation, and increased risk of miscarriage. Dysregulation of non-circadian functions of the clock genes leads to systemic endothelial dysfunction and epigenetic disorders. The disorders of circadian rhythms called desynchronoses appear when the effects of stereotypical internal (deficit and displacement of the sleeping period, typical pathological processes) and/or external (change of work schedule and time zone) environmental factors are altered.

Conclusion: Newly developed or existing disorders in the circadian organization of the maternal body may modulate a number of pathogenetic mechanisms in case of miscarriage: neurogenic, endocrine, immune, and vascular; therefore, a detailed study of the mechanisms of adaptation and integration of rhythms in the emerging multifunctional system “mother-placenta-fetus” is extremely important in obstetric practice.

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Sobre autores

Madina Baroeva

Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences; North Ossetian State Medical Academy, Ministry of Health of Russia

Autor responsável pela correspondência
Email: vip.baroeva@mail.ru
ORCID ID: 0000-0003-3978-743X

Junior Researcher at the Laboratory of Reproductology and Gestational Pathology, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences; PhD student at the Department of Obstetrics and Gynecology No. 1, North Ossetian State Medical Academy, Ministry of Health of the Russian Federation

Rússia, Vladikavkaz; Vladikavkaz

Fatima Datieva

Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences

Email: faaroo@mail.ru
ORCID ID: 0000-0002-1636-9174

Dr. Med. Sci., Director

Rússia, Vladikavkaz

Larisa Popova

Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences; North Ossetian State Medical Academy, Ministry of Health of Russia

Email: larisa_s_popova@mail.ru
ORCID ID: 0000-0003-3546-4385

PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 1, North Ossetian State Medical Academy, Ministry of Health of the Russian Federation; Senior Researcher, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences

Rússia, Vladikavkaz; Vladikavkaz

Larisa Tsallagova

Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences; North Ossetian State Medical Academy, Ministry of Health of Russia

Email: akusherstvo_1@mail.ru
ORCID ID: 0000-0003-0514-3038

Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No. 1, North Ossetian State Medical Academy, Ministry of Health of the Russian Federation; Head of the Laboratory of Reproductology and Gestational Pathology, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences, 362027, Russia, Vladikavkaz

Rússia, Vladikavkaz; Vladikavkaz

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