Characteristics of circadian regulation in patients with miscarriage
- 作者: Baroeva M.D.1,2, Datieva F.S.1, Popova L.S.1,2, Tsallagova L.V.1,2
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隶属关系:
- Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences
- North Ossetian State Medical Academy, Ministry of Health of Russia
- 期: 编号 7 (2024)
- 页面: 5-11
- 栏目: Reviews
- URL: https://journals.eco-vector.com/0300-9092/article/view/635276
- DOI: https://doi.org/10.18565/aig.2024.95
- ID: 635276
如何引用文章
详细
The article presents the analysis of circadian regulation disorders contributing to miscarriage and complicating the course of pregnancy. The circadian system of the body provides regulation of the neuroendocrine-immune (NEIM) system, dynamic balance and the process of adaptation of the female body to the developing pregnancy, and fetal growth. The autonomous circadian regulation is formed in the fetus/embryo under the influence of endogenous and exogenous signals that carry information through the placenta during normal pregnancy. The transcription factor genes CLOCK/BMAL1, the light period genes Period 1-3/Cryptochrome 1-2 and their protein products play an important role in the process of circadian regulation. Mutations in genes regulating and controlling the “clock” are accompanied in experiment and clinic by the development of pathologic conditions followed by disruption of estrous cycles, failure of embryo implantation, and increased risk of miscarriage. Dysregulation of non-circadian functions of the clock genes leads to systemic endothelial dysfunction and epigenetic disorders. The disorders of circadian rhythms called desynchronoses appear when the effects of stereotypical internal (deficit and displacement of the sleeping period, typical pathological processes) and/or external (change of work schedule and time zone) environmental factors are altered.
Conclusion: Newly developed or existing disorders in the circadian organization of the maternal body may modulate a number of pathogenetic mechanisms in case of miscarriage: neurogenic, endocrine, immune, and vascular; therefore, a detailed study of the mechanisms of adaptation and integration of rhythms in the emerging multifunctional system “mother-placenta-fetus” is extremely important in obstetric practice.
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作者简介
Madina Baroeva
Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences; North Ossetian State Medical Academy, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: vip.baroeva@mail.ru
ORCID iD: 0000-0003-3978-743X
Junior Researcher at the Laboratory of Reproductology and Gestational Pathology, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences; PhD student at the Department of Obstetrics and Gynecology No. 1, North Ossetian State Medical Academy, Ministry of Health of the Russian Federation
俄罗斯联邦, Vladikavkaz; VladikavkazFatima Datieva
Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences
Email: faaroo@mail.ru
ORCID iD: 0000-0002-1636-9174
Dr. Med. Sci., Director
俄罗斯联邦, VladikavkazLarisa Popova
Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences; North Ossetian State Medical Academy, Ministry of Health of Russia
Email: larisa_s_popova@mail.ru
ORCID iD: 0000-0003-3546-4385
PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 1, North Ossetian State Medical Academy, Ministry of Health of the Russian Federation; Senior Researcher, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences
俄罗斯联邦, Vladikavkaz; VladikavkazLarisa Tsallagova
Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences; North Ossetian State Medical Academy, Ministry of Health of Russia
Email: akusherstvo_1@mail.ru
ORCID iD: 0000-0003-0514-3038
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No. 1, North Ossetian State Medical Academy, Ministry of Health of the Russian Federation; Head of the Laboratory of Reproductology and Gestational Pathology, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences, 362027, Russia, Vladikavkaz
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