Pregnancy and labor in overweight and obese women with and without supplementation of a complex containing myoinositol and D-chiroinositol in the ratio of 5:1, manganese and folic acid

Objective: To determine the characteristics of the course of pregnancy in overweight and obese women with and without supplementation of Dikirogen complex containing myoinositol and D-chiroinositol in the ratio of 5:1, manganese and folic acid.

Materials and methods: This was a retrospective analysis of the patients’ records and obstetric histories of 70 pregnant women. The women were divided into two groups: group 1 (n=30) included overweight and obese patients who received the complex; group 2 (n=40) included overweight and obese women who did not receive the complex. The analysis of anthropometric data of pregnant women, patients’ histories, course of pregnancy and labor, neonatal condition was carried out.

Results: The incidence of gestational diabetes mellitus (GDM) was significantly lower in women who took a complex containing myoinositol and D-chiroinositol in the ratio of 5:1, manganese and folic acid: GDM was detected in 3.33% of women in the first trimester (in 15% in group 2), and in 10% in the second trimester (in 17.5% in group 2). Significant differences were noted in fasting serum glucose levels: 4.28 (0.3) mmol/l in the first trimester in group 1, 4.64 (0.4) mmol/l in group 2; 4.46 (0.4) mmol/l in the second trimester in group 1 and 4.69 (0.5) mmol/l in group 2; 4.52 (0.3) mmol/l in the third trimester in group 1 and 4.75 (0.3) mmol/l in group 2 (p<0.05).

The patients in group 2 (without supplementation) were more likely to have iron deficiency anemia: 20% in the first trimester, 57.5% in the second trimester, and 50% in the third trimester (compared to 10% in group 1 in the first trimester, 30% in the second trimester, and 10% in the third trimester). The women of group 2 more often had acute respiratory viral infections, which, apparently, were associated with impaired formation of immune cells due to iron deficiency. The patients of group 1 who received myoinositol and D-chiroinositol complex in the ratio of 5:1, manganese and folic acid had a total body weight gain of 10.1 (2.6) kg, compared to the group without supplementation who had weight gain of 14.09 (3.4) kg, i.e. it was lower by 2.85–3.07 kg (χ²=13.037, p<0.05). Perineal tears were more frequent in labor in the patients in group 2, which were most likely related to the weight of the children, as macrosomia was diagnosed in 30% of the newborns (the body weight of the newborns was lower in group 1, χ²=5.143, p=0.023). Another possible reason is the high frequency of iron deficiency anemia in the patients of group 2 and syndrome of tissue trophic disorders.

Conclusion: The prescription of the Dikirogen complex, containing myoinositol and D-chiroinositol in the ratio of 5:1, manganese and folic acid, is a method for preventing such pregnancy complications as GDM, iron deficiency anemia, acute respiratory infections, and abnormal weight gain. The women who took Dikirogen during pregnancy had a lower incidence of perineal tears in labor, and their babies were more likely to be born with normal weight.