Витамин D и рак молочной железы у женщин


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Аннотация

Исследования последних лет обнаружили связь дефицита витамина D и широкого спектра заболеваний - сердечно-сосудистой патологии, депрессии, сахарного диабета, болезни Альцгеймера и ряда онкологических заболеваний. Многочисленные исследования показали прямую связь между низким уровнем витамина D и частотой рака молочной железы, риском отдаленных метастазов и общей выживаемостью. Установлена значимость не только абсолютной концентрации витамина D, но и регулирующее влияние рецепторов витамина D и основных ферментов, определяющих локальный метаболизм витамина D. Полиморфизм гена витамина D и различная экспрессия ферментов, участвующих в синтезе биологически активной формы витамина D и катаболизме витамина, в конечном итоге определяют локальную концентрацию витамина D. Последний, в свою очередь, регулирует пролиферацию клеток молочной железы, что является основой доброкачественных поражений и онкопатологии молочной железы. Это позволяет рассматривать коррекцию дефицита витамина D как один из эффективных методов первичной профилактики рака молочной железы.

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Лариса Ивановна Мальцева

ГБОУ ДПО Казанская государственная медицинская академия Минздрава России

Email: laramalc@mail.ru
д.м.н., профессор, зав. кафедрой акушерства и гинекологии № 1

Юлия Владимировна Гарифуллова

ГБОУ ДПО Казанская государственная медицинская академия Минздрава России

Email: gamgg@yandex.ru
аспирант кафедры акушерства и гинекологии № 1

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