Витамин D и рак молочной железы у женщин
- Авторы: Мальцева Л.И.1, Гарифуллова Ю.В.1
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Учреждения:
- ГБОУ ДПО Казанская государственная медицинская академия Минздрава России
- Выпуск: № 8 (2015)
- Страницы: 33-38
- Раздел: Статьи
- URL: https://journals.eco-vector.com/0300-9092/article/view/247468
- ID: 247468
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Аннотация
Исследования последних лет обнаружили связь дефицита витамина D и широкого спектра заболеваний - сердечно-сосудистой патологии, депрессии, сахарного диабета, болезни Альцгеймера и ряда онкологических заболеваний. Многочисленные исследования показали прямую связь между низким уровнем витамина D и частотой рака молочной железы, риском отдаленных метастазов и общей выживаемостью. Установлена значимость не только абсолютной концентрации витамина D, но и регулирующее влияние рецепторов витамина D и основных ферментов, определяющих локальный метаболизм витамина D. Полиморфизм гена витамина D и различная экспрессия ферментов, участвующих в синтезе биологически активной формы витамина D и катаболизме витамина, в конечном итоге определяют локальную концентрацию витамина D. Последний, в свою очередь, регулирует пролиферацию клеток молочной железы, что является основой доброкачественных поражений и онкопатологии молочной железы. Это позволяет рассматривать коррекцию дефицита витамина D как один из эффективных методов первичной профилактики рака молочной железы.
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Об авторах
Лариса Ивановна Мальцева
ГБОУ ДПО Казанская государственная медицинская академия Минздрава России
Email: laramalc@mail.ru
д.м.н., профессор, зав. кафедрой акушерства и гинекологии № 1
Юлия Владимировна Гарифуллова
ГБОУ ДПО Казанская государственная медицинская академия Минздрава России
Email: gamgg@yandex.ru
аспирант кафедры акушерства и гинекологии № 1
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