Optimization of antiviral therapy with inosine pranobex for early injuries due to HPV-associated diseases of the cervix uteri
- Authors: Gasparyan S.A.1, Ovchinnikova O.S.1,2
-
Affiliations:
- Stavropol State Medical University
- Stavropol Territorial Clinical Consulting and Diagnostic Center
- Issue: No 9 (2015)
- Pages: 94-97
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247541
- ID: 247541
Cite item
Abstract
Objective. To optimize the treatment of early human papillomavirus virus (HPV)-associated injuries of the cervix uteri, by using a single 28-day cycle with inosine pranobex versus a triple cycle. Subjects and methods. Sixty-four patients aged 20-40 years who were infected with high-risk HPV and had cytological signs of HPV infection or low-grade squamous intraepithelial lesions (LSIL) and/or epithelial colposcopic changes corresponding to lowly atypical ones were divided into 3 subgroups according to management tactics: 1) 26 patients who took three 14-day inosine pranobex cycles at 10-day intervals; 2) 20 who received isoprinosine for 28 days; 3) 18 who were untreated. The efficiency of treatment was evaluated by PCR diagnosis, cytological examination, and colposcopy 6 months later. Results. The investigation showed the advantages of active treatment tactics versus expectant management for patients with early HPV-associated injuries of the cervix uteri. Inosine pranobex demonstrated a high efficacy in treating these diseases, with the best results being achieved in its use as three 14-day cycles at 10-day intervals.
Full Text
About the authors
Susanna A. Gasparyan
Stavropol State Medical University
Email: prof-gasp55@yandex.ru
MD, professor of Deparment of Obstetrics and Gynecology, Institute of Continuing and Additional Professional Education
Olesya S. Ovchinnikova
Stavropol State Medical University; Stavropol Territorial Clinical Consulting and Diagnostic Center
Email: olesya-gyn@yandex.ru
graduate Deparment of Obstetrics and Gynecology, Institute of Continuing and Additional Professional Education
References
- Bao Y.P., Li N., Smith J.S., Qiao Y.L. ACCPAB members. Human papillomavirus types distribution in women from Asia: a meta-analysis. Int. J. Gynecol. Cancer. 2008; 18(1): 71-9.
- Bosch F.X., Castellsagué X., de Sanjosé S. HPV and cervical cancer: screening or vaccination? Br. J. Cancer. 2008; 98(1): 15-21.
- Ашрафян Л.А., Киселёв В.И., Муйжнек Е.Л. Патогенетическая профилактика рака репродуктивных органов. М.: Димитрейд График Групп; 2009. 170с. [Ashrafyan L.A., KiselYov V.I., Muyzhnek E.L. Pathogenic prevention of cancer of the reproductive organs. Moscow: Dimitreyd Grafik Grupp; 2009. 170p. (in Russian)]
- Сухих Г.Т., Прилепская В.Н., ред. Профилактика рака шейки матки. Руководство для врачей. 3-е изд. М.: МЕДпресс-информ; 2012. 192с. [Suhih G.T., Prilepskaya V.N., eds. Prevention of cervical cancer. Guide for physicians. 3rd ed. Moscow: MEDpress-inform; 2012. 192p. (in Russian)]
- Schiffman M. Integration of human papillomavirus vaccination, cytology, and human papillomavirus testing. Cancer. 2007; 111(3): 145-53.
- Аполихина И.А., Денисова Е.Д. Папилломавирусная инфекция гениталий: актуальная проблема современной гинекологии и пути ее решения. Вопросы гинекологии, акушерства и перинатологии. 2007; 6(6): 70-5. [Apolikhina I.A., Denisova E.D. Genital HPV infection: the actual problem of modern gynecology and its solutions. Voprosyi ginekologii, akusherstva i perinatologii. 2007; 6(6): 70-5. (in Russian)]
- Дамиров М.М. Радиоволновые, криогенные и лазерные технологии в диагностике и лечении в гинекологии. М.: БИНОМ; 2011. 320с. [Damirov M.M. Radiowave, cryogenic and laser technology in the diagnosis and treatment in gynecology. Moscow: BINOM; 2011. 320p. (in Russian)]
- Чиссов В.И., Старинский В.В., Петрова Г.В., ред. Злокачественные новообразования в России в 2008 году (заболеваемость и смертность). М.: ФГУ «МНИОИ им. П.А. Герцена»; 2010. 256с. [Chissov V.I., Starinskiy V.V., Petrova G.V., eds. Malignancies in Russia in 2008 (morbidity and mortality). Moscow: FGU «MNIOI im. P.A. Gertsena»; 2010. 256p. (in Russian)]
- Insinga R.P., Dasbach E.J., Elbasha E.H. Epidemiologic natural history and clinical management of Human Papillomavirus (HPV) Disease: a critical and systematic review of the literature in the development of an HPV dynamic transmission model. BMC Infect. Dis. 2009; 9: 119-21.
- Ашрафян Л.А., Киселёв В.И. Опухоли репродуктивных органов (этиология и патогенез). М.: Димитрейд График Групп; 2007. 216с. [Ashrafyan L.A., Kiselyov V.I. Tumors of the reproductive organs (etiology and pathogenesis). Moscow: Dimitreyd Grafik Grupp; 2007. 216p. (in Russian)]
- Прилепская В.Н., Роговская С.И., Кондриков Н.И., Сухих Г.Т. Папилломавирусная инфекция: диагностика, лечение и профилактика. М.: МЕДпресс-информ; 2007. 32с.
- Дисаи Ф.Дж., Крисман У.Т. Клиническая онкогинекология. Пер. с англ. М.: Рид Элсивер; 2011. т.1. 316с. [Disai F.J., Krisman U.T. Clinical cancers. Trans. from English. Moscow: Rid Elsiver; 2011. Vol.1. 316p. (in Russian)]
- Назарова Н.М., Бестаева Н.В., Прилепская В.Н., Трофимов Д.Ю., Костава М.Н. Новые направления и дискуссионные вопросы диагностики и лечения заболеваний, ассоциированных с папилломавирусной инфекцией. Акушерство и гинекология. 2012; 5: 10-6. [Nazarova N.M., Bestayeva N.V., Prilepskaya V.N., Trofimov D.Yu., Kostava M.N. The diagnosis and treatment of papillomavirus infection-associated diseases: New directions and controversial issues. Akusherstvo i ginekologiya/Obstetrics and gynecology. 2012; (5): 10-6. (in Russian)]
- Стерн П.Л., Китченер Г.С., ред. Вакцины для профилактики рака шейки матки. Пер. с англ. Сухих Г.Т., Прилепская В.Н., ред. 3-е изд. М.: МЕДпресс-информ; 2011. 190с. [Stern P.L., Kitchener G.S., ed. Vaccines for the prevention of cervical cancer. Trans. from English Sukhikh G.T., Prilepskaya V.N., eds. 3rd ed. M.: MEDpress-inform; 2011. 190p. (in Russian)]
- Евстигнеева Н.П. Экспрессия онкобелка Е7 у пациенток с урогенитальной папилломавирусной инфекцией. Российский журнал кожных и венерических болезней. 2006; 2: 4-6. [Evstigneeva N.P. Expression of oncoprotein E7 in patients with urogenital papilloma virus infection. Rossiyskiy zhurnal kozhnyih i venericheskih bolezney. 2006; 2: 4-6. (in Russian)]
- Киселев В.И., Свешников П.Г., Барановский П.М., Липова Е.В., Глазко И.И., Ашрафян Л.А. Онкобелок Е7 вируса папилломы человека - новый маркер ранних стадий канцерогенеза. Terra Medica. 2011; 1: 35-9. [Kiselyov V.I., Sveshnikov P.G., Baranovskiy P.M., Lipova E.V., Glazko I.I., Ashrafyan L.A. Oncoprotein E7 of human papilloma virus - a new marker of early stages of carcinogenesis. Terra Medica. 2011; 1: 35-9. (in Russian)]
- Woodman C.B., Collins S., Winter H., Bailey A., Ellis J., Prior P. et al. Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study. Lancet. 2001; 357(9271): 1831-6.
- Barnard P., Payne E., McMillan N.A. The human papillomavirus E7 protein is able to inhibit the antiviral and anti-growth functions of interferon -alpha. Virology. 2000; 277(2): 411-9.
- Buitrago-Pérez A., Garaulet G., Vázquez-Carballo A., Paramio J.M., Garcia-Escudero R. Molecular signature of HPV-induced carcinogenesis: pRb, p53 and gene expression profiling. Curr. Genomics. 2009; 10(1): 26-31.
- Kodner C.M., Nasraty S. Management of genital warts. Am. Fam. Physician. 2004; 70(12): 2335-42.
- Wiley D.J., Douglas J., Beutner K., Cox T., Fife K., Moscicki A.B., Fukumoto L. External genital warts: diagnosis, treatment, and prevention. Clin. Infect. Dis. 2002; 35(Suppl.2): S210-24.
- Каратюк Т.И. Клинико-диагностические особенности цервикальных интраэпителиальных неоплазий, ассоциированных с папилломавирусной инфекцией: дисс.. канд. мед. наук. Омск; 2011. 172с. [Karatyuk T.I. Clinical and diagnostic characteristics of cervical intraepithelial neoplasia associated with HPV infection. Diss. Omsk; 2011. 172p. (in Russian)]
- Cox J.T., Schiffman M., Solomon D. Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy. Am. J. Obstet. Gynecol. 2003; 188(6): 1406-12.
- Ryu A., Nam K., Chung S., Kim J., Lee H., Koh E., Bae D. Absence of dysplasia in the excised cervix by a loop electrosurgical excision procedure in the treatment of cervical intraepithelial neoplasia. J. Gynecol. Oncol. 2010; 21(2): 87-92.
- Григорьева И.Н., Кедрова А.Г., Кузнецов В.В., Подистов Ю.И., Глазкова О.А., Афанасьева Е.А. Применение противовирусных и иммуномодулирующих лекарств у больных с преинвазивным раком шейки матки. В кн.: Материалы XI Российского онкологического конгресса. М.; 2007: 214-5. [Grigoreva I.N., Kedrova A.G., Kuznetsov V.V., Podistov Yu.I., Glazkova O.A., Afanaseva E.A. Antiviral and immunomodulating drugs in patients with preinvasive cancer of the cervix. In: Proceedings of the XI Congress of the Russian Cancer. Moscow; 2007: 214-5. (in Russian)]
- Кедрова А.Г., Подистов Ю.И., Кузнецов В.В., Брюзгин В.В., Козаченко В.П., Никогосян С.О. Роль противовирусной терапии в комплексном лечении больных эпителиальными дисплазиями и преинвазивным раком шейки матки. Гинекология. 2005; 7(3): 170-3. [Kedrova A.G., Podistov Yu.I., Kuznetsov V.V., Bryuzgin V.V., Kozachenko V.P., Nikogosyan S.O. The role of antiviral therapy in treatment of patients with epithelial dysplasia and preinvasive cervical cancer. Ginekologiya. 2005; 7(3): 170-3. (in Russian)]
- Роговская С.И., Теребнева Л.И. Клинические аспекты плоскоклеточных интраэпителиальных поражений низкой степени. Акушерство и гинекология. 2013; 2: 139-43. [Rogovskaya S.I., Terebneva L.I. Clinical aspects of low-grade squamous intraepithelial lesions. Akusherstvo i ginekologiya/Obstetrics and gynecology. 2013; (2): 139-43. (in Russian)]
- Елисеева М.Ю., Манухин И.Б., Мынбаев О.А., Зверева Н.С., Мишутина А.А., Царёв В.Н. Противовирусный эффект инозина пранобекса при ВПЧ-ассоциированных заболеваниях. Акушерство и гинекология. 2012; 2: 107-14. [Eliseeva M.Yu., Manukhin I.B., Mynbaev O.A., Zvereva N.S., Mishutina A.A., Tcarev V.N. Antiviral effect of isoprinosine in HPV-associated diseases. Akusherstvo i ginekologiya/Obstetrics and gynecology. 2012; (2): 107-14. (in Russian)]
- Кедрова А.Г., Леваков С.А., Челнокова Н.Н. Оптимизация медикаментозной терапии начальных повреждений эпителия шейки матки, ассоциированных с вирусом папилломы человека. Акушерство и гинекология. 2014; 8: 88-93. [Kedrova A.G., Levakov S.A., Chelnokova N.N. Optimization of drug therapy for early human papillomavirus-associated cervical epithelial damages. Akusherstvo i ginekologiya/Obstetrics and gynecology. 2014; (8): 88-93. (in Russian)]
- Georgala S., Katoulis A.C., Befon A., Georgala C., Rigopoulos D. Oral inosiplex in the treatment of cervical condylomata acuminata: a randomised placebocontrolled trial. Br. J. Obstet. Gynaecol. 2006; 113(9): 1088-91.