Optimization of antiviral therapy with inosine pranobex for early injuries due to HPV-associated diseases of the cervix uteri


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Abstract

Objective. To optimize the treatment of early human papillomavirus virus (HPV)-associated injuries of the cervix uteri, by using a single 28-day cycle with inosine pranobex versus a triple cycle. Subjects and methods. Sixty-four patients aged 20-40 years who were infected with high-risk HPV and had cytological signs of HPV infection or low-grade squamous intraepithelial lesions (LSIL) and/or epithelial colposcopic changes corresponding to lowly atypical ones were divided into 3 subgroups according to management tactics: 1) 26 patients who took three 14-day inosine pranobex cycles at 10-day intervals; 2) 20 who received isoprinosine for 28 days; 3) 18 who were untreated. The efficiency of treatment was evaluated by PCR diagnosis, cytological examination, and colposcopy 6 months later. Results. The investigation showed the advantages of active treatment tactics versus expectant management for patients with early HPV-associated injuries of the cervix uteri. Inosine pranobex demonstrated a high efficacy in treating these diseases, with the best results being achieved in its use as three 14-day cycles at 10-day intervals.

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About the authors

Susanna A. Gasparyan

Stavropol State Medical University

Email: prof-gasp55@yandex.ru
MD, professor of Deparment of Obstetrics and Gynecology, Institute of Continuing and Additional Professional Education

Olesya S. Ovchinnikova

Stavropol State Medical University; Stavropol Territorial Clinical Consulting and Diagnostic Center

Email: olesya-gyn@yandex.ru
graduate Deparment of Obstetrics and Gynecology, Institute of Continuing and Additional Professional Education

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