ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ СТВОЛОВЫХ И ПРОГЕНИТОРНЫХ КЛЕТОК ДЛЯ ТЕРАПИИ ПОСЛЕДСТВИЙ ГИПОКСИЧЕСКИ-ИШЕМИЧЕСКОЙ ЭНЦЕФАЛОПАТИИ НОВОРОЖДЕННЫХ


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Аннотация

Цель исследования. Провести систематический анализ исследований, посвящённых использованию клеточных технологий для лечения последствий гипоксически-ишемической энцефалопатии новорожденных. Материал и методы. В обзор включены данные зарубежных и отечественных статей по указанной теме, опубликованных в базе данных медицинских и биологических публикаций Pubmed и базе клинических испытаний ClinicalTrials.gov за последние 10 лет. Результаты. Проведен анализ различных аспектов клеточной терапии, начиная от типа стволовых клеток и источников их получения, до предполагаемых механизмов терапевтического действия. Рассмотрены компоненты, определяющие положительный эффект применительно к терапии церебральных нарушений у новорожденных, в том числе, в клинических испытаниях. Заключение. Показана высокая терапевтическая эффективность клеточных технологий и перспективность их применения в неонатологии. Тем не менее, необходимо проведение дальнейших исследований, направленных на всестороннюю характеристику типа клеток и их происхождения, дозы, оптимального времени и способа их введения для наиболее эффективного применения клеточной терапии.

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Об авторах

Геннадий Тихонович Сухих

МГУ им. М.В. Ломоносова

Email: g_sukhikh@oparina4.ru
к.б.н., с.н.с. Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского 117997, Russia, Moscow, Oparina str. 4

Денис НиколаевичПевзнер Ирина Борисовна Силачев

МГУ им. М.В. Ломоносова

Email: silachevdn@genebee.msu.ru
к.б.н., с.н.с. Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского 119992, Россия, Москва, ул. Ленинские Горы, д. 1, стр. 40, лабораторный корпус А

Ирина Борисовна Певзнер

МГУ им. М.В. Ломоносова

Email: irinapevzner@mail.ru
к.б.н., с.н.с. Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского 119992, Россия, Москва, ул. Ленинские Горы, д. 1, стр. 40, лабораторный корпус А

Любава Дмитриевна Зорова

МГУ им. М.В. Ломоносова

Email: lju_2003@list.ru
к.б.н., научный сотрудник Международного лазерного центра 119992, Россия, Москва, ул. Ленинские Горы, д. 1, стр. 62

Валентина Андреевна Бабенко

МГУ им. М.В. Ломоносова

Email: nucleus-90@yandex.ru
аспирант, м.н.с. Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского 119992, Россия, Москва, ул. Ленинские Горы, д. 1, стр. 40, лабораторный корпус А

Василий Андреевич Попков

Московский государственный университет им. М.В. Ломоносова

Email: popkov@genebee.msu.ru
аспирант, м.н.с. Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского 119992, Россия, Москва, ул. Ленинские Горы, д. 1, стр. 40, лабораторный корпус А

Станисловас Стасисович Янкаускас

Московский государственный университет им. М.В. Ломоносова

Email: stanislovas@mail.ru
аспирант, научный сотрудник Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского 119992, Россия, Москва, ул. Ленинские Горы, д. 1, стр. 40, лабораторный корпус А

Виктор Васильевич Зубков

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова

Email: v_zubkov@oparina4.ru
д.б.н., профессор, зав. отделением 117997, Russia, Moscow, Oparina str. 4

Дмитрий Борисович Зоров

МГУ им. М.В. Ломоносова

Email: zorov@genebee.msu.ru
д.б.н., профессор, зав. отделом, Научно-исследовательский институт физико-химической биологии им. А.Н. Белозерского 119992, Россия, Москва, ул. Ленинские Горы, д. 1, стр. 40, лабораторный корпус А

Егор Юрьевич Плотников

МГУ им. М.В. Ломоносова

Email: plotnikov@mail.genebee.msu.ru
д.б.н., профессор РАН, в.н.с. Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского 119992, Россия, Москва, ул. Ленинские Горы, д. 1, стр. 40, лабораторный корпус А

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