PROSPECTS FOR USING STEM AND PROGENITOR CELLS IN THE THERAPY OF CONSEQUENCES OF NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY


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Abstract

Objective. To carry out a systems analysis of investigations using cell technologies to treat the sequels of neonatal hypoxic-ischemic encephalopathy. Material and methods. The review includes the data of foreign and Russian articles published on this topic in the past 10 years in the Pubmed database of medical and biological publications and the ClinicalTrials.gov base of clinical trials. Results. Different aspects of cell therapy, from the type of stem cells and the sources of their acquisition to the presumed mechanisms of therapeutic action, were analyzed. The components determining the positive effect, as applied to therapy for neonatal cerebral disorders, including in clinical trials, were considered. Conclusion. Cell technologies have shown their high therapeutic effectiveness and promise for use in neonatology. Nevertheless, it is necessary to conduct further investigations aimed at comprehensively characterizing the type of cells and their origin, doses, and optimal time and route of their administration for the most effective use of cell therapy.

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About the authors

Gennady Tikhonovich Sukhikh

Research Center of Obstetrics, Gynecology, and Perinatology

Email: g_sukhikh@oparina4.ru
PhD, Professor, Academician of RAS, Director Moscow 117997, Ac. Oparina str. 4, Russia

Denis Nikolaevich Silachev

M.V. Lomonosov Moscow State University

Email: silachevdn@genebee.msu.ru
PhD, Senior Researcher, A.N. Belozersky Research Institute of Physicochemical Biology 119992, Russia, Moscow, Leninskye gory 1, bld. 40

Irina Borisovna Pevzner

M.V. Lomonosov Moscow State University

Email: irinapevzner@mail.ru
PhD, Senior Researcher, A.N. Belozersky Research Institute of Physicochemical Biology 119992, Russia, Moscow, Leninskye gory 1, bld. 40

Ljubava Dmitrievna Zorova

M.V. Lomonosov Moscow State University

Email: lju_2003@list.ru
PhD, Scientific Researcher, International Laser Research Center 119992, Russia, Moscow, Leninskye gory 1, bld. 40

Valentina Andreevna Babenko

M.V. Lomonosov Moscow State University

Email: nucleus-90@yandex.ru
PhD student, Junior Researcher, A.N. Belozersky Research Institute of Physicochemical Biology 119992, Russia, Moscow, Leninskye gory 1, bld. 40

Vasiliy Andreevich Popkov

M.V. Lomonosov Moscow State University

Email: popkov@genebee.msu.ru
PhD student, Junior Researcher, A.N. Belozersky Research Institute of Physicochemical Biology 119992, Russia, Moscow, Leninskye gory 1, bld. 40

Stanislovas Stasisovich Jankauskas

M.V. Lomonosov Moscow State University

Email: stanislovas@mail.ru
PhD, Researcher, A.N. Belozersky Research Institute of Physicochemical Biology 119992, Russia, Moscow, Leninskye gory 1, bld. 40

Viktor Vasilievich Zubkov

Research Center of Obstetrics, Gynecology, and Perinatology

Email: v_zubkov@oparina4.ru
PhD, Professor, Head of Department Moscow 117997, Ac. Oparina str. 4, Russia

Dmitry Borisovich Zorov

M.V. Lomonosov Moscow State University

Email: zorov@genebee.msu.ru
PhD, Professor, Head of Department, A.N. Belozersky Research Institute of Physicochemical Biology 119992, Russia, Moscow, Leninskye gory 1, bld. 40

Egor Yurievich Plotnikov

M.V. Lomonosov Moscow State University

Email: plotnikov@mail.genebee.msu.ru
PhD, Professor, Principal Scientific Researcher, A.N. Belozersky Research Institute of Physicochemical Biology 119992, Russia, Moscow, Leninskye gory 1, bld. 40

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