Внеклеточные везикулы, полученные из мультипотентных мезенхимальных стромальных клеток: патогенетическое обоснование терапевтического применения

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Аннотация

Представленный обзор научных исследований является продолжением обсуждения современных взглядов на фолликулогенез и его регуляцию.

В нем мы попытались описать возможности и перспективы применения клеточной терапии в репродуктивной медицине, а также возможные механизмы влияния стволовых клеток и их внеклеточных везикул на механизмы рекрутирования фолликулов. Перспективы применения таргетных агентов в терапии преждевременной недостаточности яичников объясняются тем фактом, что большинство примордиальных фолликулов яичников в течение всей жизни женщины остаются в спящем, неактивном состоянии. Экспериментальные исследования позволили установить основные сигнальные пути, участвующие в регуляции раннего фолликуло- и оогенеза. Изучение регуляции активности ключевых сигнальных путей позволит разработать таргеты для дальнейшего влияния на гонадотропин-независимую фазу роста фолликулов и, возможно, преодолеть такие грубые нарушения репродуктивной системы, как преждевременная недостаточность яичников и возраст-ассоциированное снижение качества и количества ооцитов.

Проведен анализ литературных данных и описаны возможные механизмы влияния клеточной терапии на состояние овариального резерва.

В обзор включены данные зарубежных статей, опубликованных в базах eLibrary.ru и PubMed по данной теме.

Заключение: Представленная информация о путях воздействия внеклеточных везикул раскрывает перспективы лечения бесплодия у сложной категории пациенток. Дальнейшие исследования механизмов функционирования, точек приложения внеклеточных везикул необходимы для расширения терапевтических возможностей.

 

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Яна Ованнесовна Мартиросян

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской Федерации

Автор, ответственный за переписку.
Email: marti-yana@yandex.ru

кандидат медицинских наук, врач акушер-гинеколог НКО ВРТ им. Ф. Паулсена

Россия, 117997, Москва, ул. Академика Опарина, д. 4

Альбина Ильдаровна Кадаева

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской Федерации

Email: albina.karimovai@mail.ru

аспирант по специальности «акушерство-гинекология»

Россия, 117997, Москва, ул. Академика Опарина, д. 4

Денис Николаевич Силачев

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской Федерации

Email: silachevdn@genebee.msu.ru

доктор биологических наук, руководитель лаборатории клеточных технологий

Россия, 117997, Москва, ул. Академика Опарина, д. 4

Татьяна Алексеевна Назаренко

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской Федерации

Email: t_nazarenko@oparina4.ru

профессор, доктор медицинских наук, директор института репродуктивной медицины

Россия, 117997, Москва, ул. Академика Опарина, д. 4

Полина Владимировна Матвеева

Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации

Email: polina.matveeva00@gmail.ru

студент

Россия, 119048, Москва, ул. Трубецкая, д. 8, стр. 2

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