RATIONAL METHODS FOR DIAGNOSIS AND THERAPY OF CHRONIC INFLAMMATORY REPRODUCTIVE SYSTEM DISEASES AFTER EARLY MISCARRIAGE

Objective. To study rational methods for diagnosis and therapy in patients with chronic inflammatory reproductive system diseases after early miscarriage. Subjects and methods. Ninety-seven patients who had had spontaneous miscarriage at 13—21 weeks of gestation were examined. The authors used clinical, bacterioscopic, bacteriological, and laparoscopic studies, enzyme immunoassay, and polymerase chain reaction to study the epithelial cells of the vagina and cervical canal of the uterus, and endometrium, as well as ultrasound study. The results of the study were statistically processed. Results. A morphological study of placental tissue and clinical and laboratory diagnostic examinations confirmed that the patients had chronic endometritis and salpyngoophoritis. Conclusion. Rational antimicrobial therapy for chronic inflammatory processes in the small pelvic reproductive organs, which promotes the elimination of infectious agents, is an important factor of pregravid preparation of patients with early miscarriage. Its use must be combined with that of agents having an antimycotic effect and those enhancing the induction of interferons.

early miscarriage, chronic placental insufficiency, placentitis, chorioamnionitis, chronic endometritis, chronic salpyngoophoritis, bacterial vaginosis, Candida-induced vaginitis, cervicitis