THE CONTENT OF MAIN SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN PREGNANT WOMEN WITH MISCARRIAGE AND ANTIPHOSPHOLIPID SYNDROME DURING INTRAVENOUS IMMUNOGLOBULIN TREATMENT


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Objective. To estimate immunological parameters and the course of pregnancy in women with miscarriage in the presence of antiphospholipid syndrome (APS) in the treatment with intravenous immunoglobulin (IVIG) preparations. Subjects and methods. Seventy-three pregnant women with miscarriage and APS, 48 women of whom received an IVIG preparation, were examined. The impact of therapy on the frequency of pregnancy complications and immunological blood was studied. Results. A reduction was found in the frequency of pregnancy complications; moreover, the ratios of lymphocyte subpopulations changed in pregnant women. The use of IVIG preparations contributes to the normalized balance of immunocompetent cells, specifically results in an increase in the level of regulatory T lymphocytes. Conclusion. The use of IVIGs favors the improvement of gestational parameters in women with miscarriage in the presence of APS, which may be mediated by their effect on the activity of regulatory lymphocyte subpopulations.

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作者简介

A. CHUGUNOVA

Acad. I.P. Pavlov Saint Petersburg State Medical University

Email: ezericshe@mail.ru
Department of Obstetrics and Gynecology Saint Petersburg

M. ZAINULINA

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Saint Petersburg

A. SELYUTIN

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Saint Petersburg

D. SOKOLOV

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Saint Petersburg

V. MIKHAILOVA

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Saint Petersburg

S. CHEPANOV

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Saint Petersburg

S. SELKOV

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Saint Petersburg

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