ROLE OF GENETIC FACTORS IN THE DEVELOPMENT OF NEONATAL RESPIRATORY DISORDERS IN PLACENTAL INSUFFICIENCY


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To study the role of gene polymorphism in pregnant women with placental insuff iciency (PI) in the realization of respiratory disorders (RD) in their neonates. Subjects and methods. A prospective study was conducted on 202 patients with PI, by investigating the distribution of alleles and genotypes of polymorphic loci in the mothers and their newborn infants. Results. The mothers with the TT genotype at -251 position of the promotor region of the IL8 gene more often gave birth to babies with further intrauterine infection realization. If the mother had A allele of ESR1 gene polymorphism: -351G>A (XbaI), the baby significantly more frequently developed respiratory distress syndrome (OR=1.85 (1.1-3.2); p=0.029). Conclusion. Our findings allow IL8 and ESR1 gene polymorphisms to be determined in pregnant women with PI as a predictor of RD in their neonates.

全文:

受限制的访问

作者简介

N. KAN

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_kan@oparina4.ru

N. LOMOVA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: natasha-lomova@yandex.ru

A. DONNIKOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru

V. ZUKBOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_zubkov@oparina4.ru

S. PAVLOVICH

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: s_pavlovich@oparina4.ru

N. DUBROVINA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_dubrovina@oparina4.ru

V. TYUTYUNNIK

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_tutunnik@oparina4.ru

G. SUKHIKH

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

参考

  1. Bonetti L., Ferrari P., Trani N., Maccio L., Laura S., Giuliana S. et al. The role of fetal autopsy and placental examination in the causes of fetal death: a retrospective study of 132 cases of stillbirths. Arch. Gynecol. Obstet. 2011: 283(2): 231—41.
  2. Brzozowska M., Kowalska-Koprek U., Kuś E., Berner-Trabska M., Karowicz-Bilińska A. Analysis of the indications for the caesarean section delivery for very low birthweight neonates (<1500 g) delivered in I department gynecology and obstetrics, Medical University in Lodz in 2006-2010. Ginekol. Pol. 2011; 82(8): 592—7.
  3. Hui L., Challis D. Diagnosis and management of fetal growth restriction: the role of fetal therapy. Best Pract. Res. Clin. Obstet. Gynaecol. 2008; 22(1): 139—58.
  4. Gibbons K., Beckmann M., Flenady V., Rossouw D., Gardener G., Mahomed K. et al. A survey of policies for the monitoring of fetal growth in Australian and New Zealand hospitals. Aust. N. Z. J. Obstet. Gynaecol. 2011; 51(6): 493—8.
  5. Bose C., Van Marter L.J., Laughon M., O’Shea T.M., Allred E.N., Karna P. et al. Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation. Extremely Low Gestational Age Newborn Study Investigators. Pediatrics. 2009; 124(3): e450—8.
  6. Hallman M., Marttila R., Pertile R., Ojaniemi M., Haataja R. Genes and environment in common neonatal lung disease. Neonatology. 2007; 91(4): 298—302.
  7. Bizzarro M.J., Jiang Y., Hussain N., Gruen J.R., Bhandari V., Zhang H. The impact of environmental and genetic factors on neonatal late-onset sepsis. J. Pediatr. 2011; 158(2): 234—8; e1.
  8. Özkan H., Köksal N., Çetinkaya M., Kiliç Ş., Çelebi S., Oral B., Budak F. Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia. J. Perinatol. 2012; 32(3): 210—7.
  9. Remick D.G. Interleukin-8. Crit. Care Med. 2005; 33: 466—7.
  10. Ebina M., Shimizukawa M., Shibata N., Kimura Y., Suzuki T., Endo M. et al. Heterogeneous increase in CD34-positive alveolar capillaries in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2004; 169(11): 1203—8.
  11. Ahn M.H., Park B.L., Lee S.H., Park S.W, Park J.S., Kim D.J. et al. A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode. Respir. Res. 2011; 12: 73.
  12. Hull J., Thomson A., Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax. 2000; 55(12): 1023—7.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2013
##common.cookie##