ENDOMETRIAL MORPHOLOGICAL AND IMMUNIHISTOCHEMICAL FEATURES IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA AS A BASIS FOR THE DEVELOPMENT OF OBSTETRIC COMPLICATIONS


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详细

Objective. To investigate endometrial morphological and molecular genetic features in undifferentiated connective tissue (CT) dysplasia (UDCTD). Subject and methods. The investigation included 90 patients aged 18 to 45 years who were divided into 2 groups according to the phenotypic signs of UDCTD. Histological and immunohistochemical studies of the myometrium were conducted. The data were statistically processed using the free WINPEPI version 9.7 software. Results. The morphological and molecular genetic features of the myometrium in UDCTD were examined and the immunohistochemical manifestations of disorganized myometrial CT were determined in UDCTD. Conclusion. The morphological signs of UDCTD are the detected foci of disorganized CT with its diminished vascularization, evolved foci of mucoid and fibrinoid swelling, manifestation of stromal edema, focal hemorrhage, and interstitial sclerosis, as well as lymphohistiocytic stromal infiltrate. The immunohistochemical manifestations of disorganized myometrial CT in UDCTD include collagen III accumulation, decreased vascularization with higher collagen IV and lower laminin in the extracellular matrix. The found changes may provide a basis for the higher incidence of obstetric complications in UDCTD.

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作者简介

N. KAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: n_kan@oparina4.ru
Moscow

V. TYUTYUNNIK

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: v_tioutiounnik@oparina4.ru
Moscow

M. KESOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: m_kesova@oparina4.ru
Moscow

T. DEMURA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: t_demura@oparina4.ru
Moscow

O. SERGUNINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: o_sergunina@oparina4.ru
Moscow

N. TYUTYUNNIK

N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: n_tioutiounnik@mail.ru
Obstetrics and Gynecology Department Two, Therapeutic Faculty Moscow

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