ENDOMETRIAL MORPHOLOGICAL AND IMMUNIHISTOCHEMICAL FEATURES IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA AS A BASIS FOR THE DEVELOPMENT OF OBSTETRIC COMPLICATIONS

Objective. To investigate endometrial morphological and molecular genetic features in undifferentiated connective tissue (CT) dysplasia (UDCTD). Subject and methods. The investigation included 90 patients aged 18 to 45 years who were divided into 2 groups according to the phenotypic signs of UDCTD. Histological and immunohistochemical studies of the myometrium were conducted. The data were statistically processed using the free WINPEPI version 9.7 software. Results. The morphological and molecular genetic features of the myometrium in UDCTD were examined and the immunohistochemical manifestations of disorganized myometrial CT were determined in UDCTD. Conclusion. The morphological signs of UDCTD are the detected foci of disorganized CT with its diminished vascularization, evolved foci of mucoid and fibrinoid swelling, manifestation of stromal edema, focal hemorrhage, and interstitial sclerosis, as well as lymphohistiocytic stromal infiltrate. The immunohistochemical manifestations of disorganized myometrial CT in UDCTD include collagen III accumulation, decreased vascularization with higher collagen IV and lower laminin in the extracellular matrix. The found changes may provide a basis for the higher incidence of obstetric complications in UDCTD.

undifferentiated connective tissue dysplasia, myometrium, connective tissue disorganization, collagen, laminin