Investigation of the myofibroblast layer separating the placenta from its bed
- 作者: Krasnyi A.M.1, Savilova A.M.1, Tetruashvili N.K1, Sukhikh G.T1
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隶属关系:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- 期: 编号 12 (2014)
- 页面: 71-73
- 栏目: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247306
- ID: 247306
如何引用文章
详细
Objective. To examine the maternal placental cytotrophoblast layer and to reveal the contractile capacities of its cells. Subjects and methods. Seven placentas from 25-30-year-old women with uncomplicated pregnancy and labor were examined. Fluorescent immunohistochemical staining of the maternal placenta was carried out. Anticytokeratin 7 and anti-alpha smooth muscle actin antibodies were used. Results. The apical surface of the placenta was shown to be covered with the myofibroblast network limiting the cytotrophoblast layer. Conclusion. The competence and activity of the myofibroblast network located in the apical portion of the cytotrophoblast layer can determine the normal separation of the placenta from the uterus during labor.
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作者简介
Aleksey Krasnyi
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: a_krasnyi@oparina4.ru
PhD Head. Laboratory of Cytology
Anastasia Savilova
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: a_savilova@oparina4.ru
PhD Head. Laboratory of Cell Technology
N. Tetruashvili
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
G. Sukhikh
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
参考
- Blaschitz A., Weiss U., Dohr G., Desoye G. Antibody reaction patterns in first trimester placenta: implications for trophoblast isolation and purity screening. Placenta. 2000; 21(7): 733-41.
- Pollheimer J., Knöfler M. The role of the invasive, placental trophoblast in human pregnancy. Wien. Med. Wochenschr. 2012; 162(9-10): 187-90.
- Knöfler M., Pollheimer J. IFPA Award in Placentology lecture: molecular regulation of human trophoblast invasion. Placenta. 2012; 33(Suppl.): S55-62.
- Caniggia I., Mostachfi H., Winter J., Gassmann M., Lye S.J., Kuliszewski M. et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J. Clin. Invest. 2000; 105: 577-87.
- Tseng J.J., Chou M.M., Hsieh Y.T., Wen M.C., Ho E.S., Hsu S.L. Differential expression of vascular endothelial growth factor, placenta growth factor and their receptors in placentae from pregnancies complicated by placenta accreta. Placenta. 2006; 27(1): 70-8.
- Gabbiani G. Evolution and clinical implications of the myofibroblast concept. Cardiovasc. Res. 1998; 38(3): 545-8.
- Отеллин В.А., Павлова И.Т., Коржевский Д.Э., Неокесарийский А.А., Старорусская А.Н. Организация и цитохимические особенности барьерных структур плаценты человека. Морфология. 2006; 3: 63-4. [Otellin V.A., Pavlova I.G., Korzhevskiy D.E., Neokesariyskiy A.A., Starorusskaya A.N. Organization and cytochemical features of human placental barrier structures. Morfologiya. 2006; 3: 63-4. (In Russian)]
- Zhuang L.Z., Li R.H. Study on reproductive endocrinology of human placenta (II)-Hormone secreting activity of cytotrophoblast cells. Sci. China B. 1991; 34(9): 1092-7.
- Van Oosterhout A.J., Celeda L., de Wied D., Nijkamp F.P. Beta-endorphin modulates anaphylactic contractions of tracheae isolated from actively sensitized guinea pigs. Agents Actions. 1990; 30(1-2): 89-91.
- Valencia-Hernández I., Reyes-Ramírez J.A., Urquiza-Marín H., Nateras-Marín B., Villegas-Bedolla J.C., Godínez-Hernández D. The effects of 17ß-oestradiol on increased а(1)-adrenergic vascular reactivity induced by prolonged ovarian hormone deprivation: the role of voltage-dependent L-type Ca channels. Pharmacology. 2012; 90(5-6): 316-23.
- Failli P., Nistri S., Mazzetti L., Chiappini L., Bani D. Effects of relaxin on vascular smooth muscle and endothelial cells in normotensive and hypertensive rats. Ann. N. Y. Acad. Sci. 2005; 1041: 311-3.
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