ASPHYXIA IN FULL-TERM NEWBORN INFANTS: COMBINATION THERAPY USING CRANIOCEREBRAL HYPOTHERMIA


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Objective. To define the role of craniocerebral hypothermia (CCH) in combination therapy for posthypoxic cerebral lesions in children. Subjects and methods. Labor and delivery histories were studied in 46 pregnant women and their babies with birth asphyxia. All the babies underwent CCH in addition to conventional clinical, laboratory, and instrumental studies. Results. There were the following significant risk factors of asphyxia: fat metabolic disturbances, gestosis (preeclampsia), a pathological preliminary period, uterine inertia, premature placental detachment, prolonged pregnancy, and chorioamnionitis. The main causes of asphyxia were umbilical cord abnormalities (41.9%), chronic fetal hypoxia, (25.6%), infection (14.0%), and a combination of these factors and abnormal labor. All the infants survived and they were switched to the second nursing care stage; only 3 (7.0%) babies developed infantile cerebral paralysis (ICP) at the age of 1 year. Conclusion. As compared to conventional therapy, CCHfor babies with birth asphyxia contributes to an increase in the number of healthy infants and to a reduction in the incidence of ICP by 2-2.5 times.

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作者简介

Galina Savelyeva

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: gms@cfp.ru
academician RAMS, MD, professor, Head of the department of obstetrics and gynecology, Pediatrics Faculty Moscow 117209, Sevastopolsky pr-t 24a, Russia

Raisa Shalina

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: raisa.shalina@gmail.com
MD, Professor of the department of obstetrics and gynecology Moscow 117209, Sevastopolsky pr-t 24a, Russia

Alexandra Smirnova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: salexandra2006_0@mail.ru
PhD student of the department of obstetrics and gynecology, Pediatrics Faculty Moscow 117209, Sevastopolsky pr-t 24a, Russia

Janna Kunyah

Center for Family Planning and Reproduction, Moscow Healthcare Department

Email: kunzhan2007@rambler.ru
doctor of the highest category, Head of Intensive care unit for premature and newborn Moscow 117209, Sevastopolsky pr-t 24a, Russia

Olga Evstratova

Center for Family Planning and Reproduction, Moscow Healthcare Department

Email: Evstratola@gmail.com
the physician anesthesiologist, Intensive care unit for premature and newborn Moscow 117209, Sevastopolsky pr-t 24a, Russia

Maria Simuhina

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: msimuhina@gmil.com
clinical intern of the department of obstetrics and gynecology, Pediatrics Faculty Moscow 117209, Sevastopolsky pr-t 24a, Russia

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