SUCCESSFUL PREGNANCY OUTCOME IN A PATIENT WITH RECURRENT MISCARRIAGE AND PLACENTAL INSUFFICIENCY CAUSED BY HIGH-RISK THROMBO PHILIA


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Description. The paper describes a case of successful treatment for thrombophilic disorders in repeated pregnancy woman with a complicated obstetric history (antenatal fetal deaths at 25 weeks’ gestation) and a complicated course of this pregnancy (placental insufficiency). The pregnant woman at 31 weeks’ gestation underwent urgent delivery because of the worse condition of her fetus. High-risk thrombophilia gene polymorphism (heterozygous factor V Leiden polymorphism) was timely revealed during this pregnancy; therapy with low molecular-weight heparins (LMWH) was initiated; prophylaxis of fetal respiratory distress syndrome was made. The patient was discharged in a satisfactory condition on day 6 after 6-week LMWH therapy.

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作者简介

Anna Dyakonova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: ann-diakonova@yandex.ru
Candidate of Medical Sciences, Researcher, Second Obstetric Department of Pregnancy Pathology 117997, Russia, Moscow, Ac. Oparina str. 4

Anna Agadzhanova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: tetrauly@mail.ru
MD, Leading Researcher, Second Obstetric Department of Pregnancy Pathology 117997, Russia, Moscow, Ac. Oparina str. 4

Natalya Fedorova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: natasha_fedorova@mail.ru
Physician, Second Obstetric Department of Pregnancy Pathology 117997, Russia, Moscow, Ac. Oparina str. 4

Nana Tetruashvili

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: tetrauly@mail.ru
MD, Second Obstetric Department of Pregnancy Pathology 117997, Russia, Moscow, Ac. Oparina str. 4

Tatiana Shubina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: t_shubina@oparina4.ru
MD, senior researcher of 2nd obstetric department of pathology of pregnancy 117997, Russia, Moscow, Ac. Oparina str. 4

Sergey Voevodin

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: e_voevodin@oparina4.ru
MD, Phd, Division of Visual Diagnostics 117997, Russia, Moscow, Ac. Oparina str. 4

参考

  1. Блинецкая С.Л. Основные наследственные тромбофилии и их роль при привычном невынашивании беременности: автореф. дисс. ... канд. мед. наук. М.; 2009. 26с
  2. Джобава Э.М. Роль молекулярных и генетических факторов тромбофилии в генезе неразвивающейся беременности и начавшегося выкидыша: автореф. дисс. . канд. мед. наук. М.; 2005. 28с
  3. Калашникова Е.А., Кокаровцева С.Н. Ассоциация наследственных факторов тромбофилии с невынашиванием беременности у женщин в русской популяции. Медицинская генетика. 2005; 4(8): 86-90
  4. Aksoy M., Tek I., Karabulut H., Berker B., Soylemez F. The role of thrombofilia related to Factor V Leiden and Factor II G20210A mutations in recurrent abortions. J. Рак. Med. Assoc. 2005; 55(3): 104-8.
  5. Coulam C.B., Jeyendran R.S., Fishel L.A., Roussev R. Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage. Am. J. Reprod. Immunol. 2006; 55(5): 360-8.

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