THE FUNCTIONAL STATE OF THE CARDIOVASCULAR SYSTEM IN PREGNANT WOMEN WITH TYPE 1 DIABETES MELLITUS


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Objective. To establish the specific functions of the cardiovascular system in pregnant women with diabetes mellitus (DM) during gestation. Subjects and methods. The results of examinations were analyzed in 204 women with type 1 DM, including 45 (22%i), 110 (54%), and 49 (24%) patients in the first, second, and third trimesters of pregnancy, respectively. A control group comprised 30 women with uncomplicated pregnancy, including 10 (33.3%), 10 (33.3%), and 1 (33.3%) patients in the first, second, and third trimesters, respectively. The patients underwent instrumental examination: echocardiography and Doppler echocardiography; the standard echocardiographic characteristics were assessed in relation to the presence of diabetic nephropathy. The examined pregnant women had neither respiratory nor heart failure. The findings were statistically analyzed. Results. The paper gives new evidence for the functional status of the cardiovascular system in pregnant women with type 1 DM. The examined patients with DM were ascertained to have a significant increase in glycated hemoglobin and to have no protective hypervolemia or hyperdynamic circulation inherent to the development of pregnancy. Conclusion. The course of pregnancy in patients with DM was characterized by hyperglycemia. Glycated hemoglobin levels during gestation were elevated and ranged from 9.54 to 8.18%. The course of pregnancy in the women with DM was unattended by significant echo-CG morphometric changes provided that DM was corrected. The patients with this condition were found to have no protective hypervolemia or hyperdynamic circulation typical of the development of pregnancy. The function of the cardiovascular system in pregnant women with diabetic nephropathy during gestation is characterized by the decreased cardiac output; the required minute volume is maintained by increased heart rate.

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作者简介

I. KANUS

Belorussian Medical Academy of Postgraduate Education

Email: rimwlad@gmail.com
MD, Professor, Department of Anaesthesiology and Reanimatology Minsk 220013, p. Brovki str. 3, bid. 3, Republic of Belarus

V. RIMASHEVSKY

Belorussian Medical Academy of Postgraduate Education

Email: rimwlad@gmail.com
PhD, Professor, Department of Anaesthesiology and Reanimatology Minsk 220013, p. Brovki str. 3, bid. 3, Republic of Belarus

T. SKRIPLENOK

Mother and Child Republican Scientific and Practical Center

Email: tnskrip@yandex.ru
MD Minsk 220053, Orlovskaya str. 66, Republic of Belarus

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