Significance of vitamin D deficiency correction in the combination treatment of metabolic disorders in patients with polycystic ovary syndrome
- 作者: Matveeva M.V.1, Samoilova J.G.2
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隶属关系:
- MAMME Clinic Ltd Company
- Siberian State Medical University, Ministry of Health of Russia
- 期: 编号 4 (2016)
- 页面: 64-70
- 栏目: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247646
- DOI: https://doi.org/10.18565/aig.2016.4.64-70
- ID: 247646
如何引用文章
详细
Objective. To assess 25(OH)D deficiency correction in the combination treatment of metabolic disorders in patients with polycystic ovary syndrome (PCOS). Subject and methods. A total of 44 patients aged 31.32±5.05 years with PCOS were examined and randomized into 2 groups: 1) patients who received combined oral contraceptives (COC), biguanides, and colecalciferol; 2) those who used COC and biguanides. A comparison group consisted of 22 healthy women matched for gender and age. PCOS was verified in accordance with the 2012 ESHRE/ASRM diagnostic criteria. 25(OH) vitamin D (ng/ml) was measured by enzyme immunoassay. Fasting glucose and insulin and HOMA insulin resistance index were investigated. The Beck Depression Inventory was applied. The data were processed using the R-system. Results. The patients with PCOS were found to have obvious 25(OH)D deficiency associated with hyperandrogenism, hyperglycemia, hyperinsulinemia, insulin resistance, and depression. The administration of colecalciferol led to better carbohydrate metabolism, alleviated the manifestations of PCOS, and reduced waist circumference, waist-hip ratio, and depression. Conclusion. Correction of 25(OH)D deficiency contributes to the improvement of metabolic and psychological parameters and fertility.
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作者简介
Maria Matveeva
MAMME Clinic Ltd Company
Email: matveeva.mariia@yandex.ru
endocrinologist of advisory department Advisory Branch, MAMME Clinic Ltd Company.
Julia Samoilova
Siberian State Medical University, Ministry of Health of Russia
Email: samoilova_y@inbox.ru
Ph.D., Professor, Department of Endocrinology and Diabetology
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补充文件
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